Axhidrox cream is a topical antiperspirant drug, with the active ingredient being clotrimazole bromide. It works by antagonizing muscarinic acetylcholine receptors, inhibiting the secretion of axillary sweat glands, and is used to improve the symptoms of severe primary axillary hyperhidrosis in adults. Long term use can maintain efficacy and safety control.

1、 Drug name

Axhidrox cream contains 2.2mg of Axhidrox per pump press.

II. Indications

Used for local treatment of severe primary axillary hyperhidrosis in adults and adolescents aged 12 and above.

3、 Specifications and characteristics

1. Each gram of cream contains 8mg of glycopyrrolate; Each pump press releases 270mg of cream, equivalent to 2.2mg of glycopyrrolate.

2. The specification is 50g/tube, with approximately 124 compressions (i.e. 31 bilateral axillary treatments).

3. The cream is a white and glossy cream.

4、 Main components

The active ingredient is glycopyrrolate.

5、 Usage and dosage

1. For axillary skin only, press twice on each side of the armpit (i.e. 4.4mg of Bromonium Bromide per side, for a total of 540mg cream).

2. Initial treatment (first 4 weeks): once daily, recommended to apply at night.

3. Maintenance therapy (starting from week 5): can be reduced to twice a week based on the decrease in sweating.

4. First use requires exhaust: tilt the pump head and press until cream comes out, then press completely 10 times and discard the discharged cream.

5. Application method: Press the pump head twice onto the pump cover, evenly apply the cream to the armpit with the pump cover, and repeat the operation on the other side. Immediately clean the pump cover and hands with soap and water after application.

6、 Dose adjustment

1. Renal function impairment: mild to moderate can be used according to the recommended dosage; For patients with severe or end-stage renal disease (eGFR<30mL/min/1.73m ²) who require dialysis, it should only be used when the expected benefits outweigh the risks.

2. Liver function impairment: No need to adjust dosage.

3. Elderly people (≥ 65 years old): Safety and efficacy have not been established.

4. Children (<12 years old): Safety and efficacy have not been established.

7、 Medication precautions

1. Application timing: No specific requirements before or after meals, recommended for use at night.

2. Omission: The material has not been clearly processed for omission. It is recommended to use it regularly once a day as usual.

3. Vomiting: Topical application, vomiting does not affect medication.

4. Other important notes:

Apply only with the pump cover, do not use fingers; Avoid contact with eyes, mouth, and nose; If in contact, rinse immediately with plenty of water.

After applying the medication, avoid skin to skin contact with others and cover with clothing.

When there is obvious inflammation or damage to the armpit skin, wait for recovery before use.

May cause dry mouth, pay attention to oral hygiene, and prevent dental caries.

Benzyl alcohol and cetearyl alcohol may cause local allergies or skin reactions.

8、 Medication for special populations

1. Pregnancy: Available, but caution is required.

2. Breastfeeding period: Infants should avoid contact with cream or medicated skin. It is necessary to weigh the benefits of breastfeeding and treatment before deciding whether to discontinue medication or breastfeeding.

3. Fertility: Animal studies have shown that high exposure affects female fertility, with low clinical relevance.

4. Patients with severe prostatic hyperplasia, bladder neck obstruction, and history of urinary retention: use with caution, stop taking medicine immediately and seek medical advice in case of dysuria, bladder fullness, etc.

5. Coronary heart disease, heart failure, arrhythmia, and hypertension: use with caution.

6. Individuals with blood-brain barrier dysfunction (such as traumatic brain injury, radiotherapy and chemotherapy, craniotomy surgery, intravenous drug use): Use only when other treatments are ineffective.

9、 Adverse reactions

1. Common (≥ 1%): Local reactions (15.3%), dry mouth (12.3%), dry eyes (3.3%), headache (1.3%), dry skin (1.3%), dry nose (1.5%), constipation (1.3%), blurred vision (1.1%).

2. Rare: dry lips, bloating, hard stools, salivation, indigestion, nausea, eye itching, eye congestion, uneven pupils, eye irritation, dilated pupils, sore throat, tight throat, dry throat, nasal congestion, dizziness, drowsiness, poor sleep, attention disorders, head discomfort, sleep disorders, anxiety, irritability, dizziness, excessive sweating, itching, rash, skin odor, erythema, psoriasis, irritation, dry hands, atopic dermatitis, eczema, plaques, acne, urticaria, local folliculitis, pustules, thrombocytopenia, tachycardia, allergies, angioedema, urinary disorders, QT prolongation, elevated liver enzymes, elevated conjugated bilirubin, increased average red blood cell volume, decreased average hemoglobin concentration, etc. The sentence is:.

3. Adolescents: Clinical trials have reported dry eyes (2.4%) and elevated conjugated bilirubin (2.4%).

10、 Contraindications

1. Individuals who are allergic to Bromonium Bromide or any excipients.

2. Diseases that may be exacerbated by anticholinergic effects, such as glaucoma, paralytic intestinal obstruction, unstable cardiovascular status during acute bleeding, severe ulcerative colitis, toxic megacolon, myasthenia gravis, and Sjogren's syndrome.

11、 Drug interactions

1. No interaction studies have been conducted.

2. Co administration with other anticholinergic drugs (such as topiramate, sedatives, antihistamines, tricyclic antidepressants, monoamine oxidase inhibitors, tranquilizers, antipsychotics, COPD/asthma anticholinergic drugs, opioids) may increase anticholinergic effects.

12、 Storage method

1. No special storage conditions are required.

2. Valid for 3 years, it can be used for up to 12 months after the first press.

Axhidroxinformation