Voxzogo, as a bone growth regulator, has side effects mainly involving injection site reactions, systemic reactions, and specific systemic effects. The following is a layered explanation from common adverse reactions to serious complications, with particular emphasis on the specific manifestations of injection site reactions and hypotension.

1. Injection site reaction

The incidence rate is about 15-20%, manifested as local pain, erythema, or induration. Usually mild and self relieving within 72 hours, it is recommended to change the injection site each time. Ice compress can reduce swelling and avoid heat compress or massage stimulation.

2 Hypotension related reactions

About 5% of patients experience orthostatic hypotension, manifested as dizziness or blurred vision. It is recommended to sit for 10 minutes after injection and move slowly when getting up. Severe cases require assessment of blood volume status.

2.1 Requirements for blood pressure monitoring

Blood pressure should be monitored before and after the first administration, and elderly patients are advised to self test at home. When the systolic blood pressure remains below 90mmHg, dose adjustment should be considered, and immediate medical attention should be sought if accompanied by bradycardia.

3 Other common side effects

Including headaches (12%), joint pain (9%), and mild fever. The incidence of gastrointestinal symptoms such as nausea and vomiting is about 7%, and it is recommended to take medication after meals. These reactions are mostly temporary and can be gradually tolerated with continued medication.

4 Serious Adverse Reaction Warning

The incidence of hypersensitivity reactions is less than 1%, but attention should be paid to symptoms such as facial swelling or difficulty breathing. Animal experiments have shown a potential risk of epiphyseal premature closure, and pediatric patients need to monitor their bone age every 3 months. Prohibited during pregnancy.

4.1 Laboratory Abnormalities

Reversible elevation of ALT is observed in 3% of patients, and it is recommended to perform baseline and monthly liver function tests. Hypoglycemia is usually asymptomatic, but when combined with diuretics, monitoring should be strengthened.