Propafenovir hydrochloride is a competitive anticholinergic drug that has a calcium channel antagonistic effect. It increases the maximum capacity of the bladder by inhibiting excessive activity of the detrusor muscle, thereby improving symptoms such as urinary frequency, urgency, and urgency.

1、 Drug name

Metonorm Hydrochloride Tablets ® 15mg film coated tablets, also known as Proparinehydrochloride in English.

2、 Indications

Used for the treatment of symptoms related to overactive bladder (ORB) and difficulty in controlling urination caused by spinal cord problems. Its mechanism of action is to inhibit bladder contraction and increase bladder capacity.

3、 Specifications and characteristics

Appearance: White film coated sheet.

4、 Main components

Active ingredient: Propafenovir hydrochloride.

5、 Usage and dosage

1. Adults and elderly people: The commonly used dosage is 2-3 tablets (30-45mg) per day, and some patients can take 1 tablet (15mg) per day to take effect. The maximum recommended daily dose is 45mg.

2. Children and adolescents: Not recommended for use.

6、 Dose adjustment

During long-term treatment, a small number of patients may experience reversible changes in liver enzymes, so liver function should be monitored. When adverse reactions occur, they can be reduced or discontinued, and usually resolved within 1-4 days.

7、 Medication precautions

1. Before and after meals: The whole tablet should be swallowed before meals and taken with sufficient water.

2. Omission: If missed, make up for it as soon as possible; If the next dose is approaching, skip the missed dose and take the next dose on time. Do not double the dose.

3. Vomiting: The instructions do not explicitly mention the treatment recommendations after vomiting. It is recommended to consult a doctor or pharmacist.

4. Other: Take medication at a fixed time every day.

8、 Medication for special populations

1. Pregnant, breastfeeding, suspected or planned pregnancy: prohibited.

2. For patients with liver disease (moderate to severe), kidney disease, severe heart failure, prostate hyperplasia, recurrent urinary tract infections, urinary tract tumors, glaucoma, autonomic neuropathy, hiatal hernia with reflux esophagitis, arrhythmia, and tachycardia: it is necessary to inform the doctor and have the doctor evaluate whether it is usable.

3. Lactose intolerant individuals: This product contains lactose, please consult a doctor.

9、 Adverse reactions

1. Very common (≥ 1/10): dry mouth.

2. Common (≤ 1/10): abnormal vision, difficulty focusing, fatigue, headache, abdominal pain, indigestion, constipation.

3. Not common (≤ 1/100): nausea, vomiting, dizziness, tremor, urinary retention, flushing, taste change, blood pressure drop with somnolence, itching, and dysuria.

4. Rare (≤ 1/1000): rash, tachycardia.

5. Very rare (≤ 1/10000): palpitations, restlessness, and confusion of consciousness.

6. Unknown frequency: hallucinations, speech disorders.

7. Serious situation: Acute onset of glaucoma (see color halo, severe eye pain), allergic reactions (wheezing, difficulty breathing, edema, rash, blisters, etc.) may occur, and medication should be stopped immediately and medical attention sought.

8. All adverse reactions are mostly temporary and can subside within 1-4 days after dose reduction or discontinuation.

10、 Contraindications

1. Individuals who are allergic to any ingredient of this product.

2. Intestinal obstruction.

3. Bladder outlet obstruction (difficulty urinating).

4. Myasthenia gravis.

5. Loss of intestinal peristalsis function (intestinal weakness).

6. Severe ulcerative colitis.

7. Toxic megacolon.

8. Uncontrolled angle closure glaucoma (elevated intraocular pressure).

9. Moderate to severe liver disease.

10. Rapid and irregular arrhythmia (such as tachycardia, arrhythmia).

11、 Drug interactions

Interactions may occur when used in combination with antidepressants (such as imipramine, clomipramine, amitriptyline), sedatives and sleeping pills (such as benzodiazepines), oral or injectable anticholinergic drugs, amantadine, nerve blockers (such as promazine, olanzapine, quetiapine), beta agonists, cholinergic agonists (such as carbapenem, pilocarpine), isoniazid, metoclopramide, methimazole, and antifungal drugs (such as ketoconazole, itraconazole). Please inform the doctor of all medications being used.

12、 Storage method

1. Keep out of sight and reach of children everywhere.

2. No special storage conditions are required.

3. After expiration (see the expiration date on the blister and paper box), it cannot be used. The expiration date refers to the last day of the month.

13、 Manufacturer

APOGEPHAArzneimittelGmbH。

Mictonorminformation