Metformin is a specific inhibitor of adrenal steroid biosynthesis. Its target focuses on the 11- β hydroxylase in adrenal cortex cells, which blocks the final synthesis steps of cortisol and corticosterone, thereby relieving the negative feedback regulation of endogenous cortisol on pituitary adrenocorticotropic hormone (ACTH).

One Drug name:

1. Product Name: Metopirone

2. Common name: Metyrapone

II indication:

Metformin is used in combination with other diagnostic tests to diagnose adrenal insufficiency in adult and pediatric patients.

Three specifications:

250mg capsules.

4 Main ingredients:

Main ingredient: Metformin.

Five Usage and dosage:

Single dose short test: The recommended dose for adult and pediatric patients is 30 milligrams per kilogram (up to 3 grams of metoprolol), taken at midnight with milk/yogurt or snacks. Collect blood samples for testing the next morning.

VI Dose adjustment:

Medications that affect pituitary or adrenal cortex function should be discontinued based on their half-life to avoid interfering with the metoprolol test.

7 Medication precautions:

1. Before and after meals: It is not specified whether to take before or after meals, but it is recommended to take it together with milk/yogurt or snacks.

2. Missing server: No suggestions for handling missing server were provided.

3. Vomiting: If vomiting occurs after taking medication, it may affect drug absorption and test results. It is necessary to consult a doctor.

4. Other: Prior to testing, the responsiveness of the patient's adrenal gland to exogenous ACTH should be evaluated; The test should be conducted in the hospital and closely monitored to prevent suspected adrenal insufficiency.

8 Medication for special populations:

1. Pregnant women: Lack of sufficient data to determine drug-related risks, drugs can cross the placenta and may reduce fetal cortisol production.

2. Breastfeeding women: Metformin and its active metabolites are present in human milk, and their effects on nursing infants are unknown.

3. Pediatric patients: can be used to diagnose adrenal insufficiency, with the same usage and dosage as adults.

4. Elderly patients: Clinical studies did not include a sufficient number of patients aged 65 and above to determine whether their reactions were different from those of younger patients.

5. Patients with liver dysfunction: Cirrhotic patients may have impaired response to metoprolol.

Nine Adverse reactions:

Common adverse reactions include hypotension, nausea, vomiting, abdominal discomfort or pain, headache, dizziness, sedation, allergic rash, leukopenia, anemia, and/or thrombocytopenia.

Ten contraindication:

1. Patients with adrenal cortex dysfunction.

2. Patients who are allergic to metoprolol or any of its excipients.

Eleven Drug interactions:

1. Anticonvulsants, psychotropic drugs, hormone preparations, corticosteroids, antithyroid drugs, and cyproheptadine may affect the results of the metoprolol test.

2. Metformin inhibits the glucuronidation of acetaminophen, which may increase the risk of adverse reactions related to acetaminophen. Simultaneous use should be avoided.

Twelve Storage method:

1. Store at room temperature of 20 ℃ to 25 ℃ (68 ℉ to 77 ℉), allowing fluctuations between 15 ℃ to 30 ℃ (59 ℉ to 86 ℉).

2. Keep the container tightly closed and prevent heat and moisture.

Metyraponeinformation