As an anti androgen drug, the side effects of Androcur acetate tablets mainly involve endocrine, liver, and metabolic systems, which can be alleviated through dose adjustment and monitoring methods. The following is an explanation from three aspects: common side effects, serious adverse reactions, and coping strategies, with a focus on key issues such as liver dysfunction and thrombotic risk.

1. Common tolerable side effects

(1) Endocrine system

Breast swelling and pain (12% -40%): It is recommended to wear supportive underwear, which usually subsides after 2-3 months of adaptation.

Decreased libido (10% -30%): dose related, lowest effective dose maintenance therapy may be considered.

(2) Digestive system

Nausea (5% -15%): Taking medication after meals can alleviate it, but if vomiting persists, electrolyte balance needs to be evaluated.

Weight gain (3% -10%): It is recommended to regularly monitor BMI and adjust it with diet and exercise.

2. Side effects requiring medical intervention

(1) Liver toxicity

Elevated transaminase levels (1% -5%): Liver function should be monitored monthly for the first 6 months of treatment, and medication should be discontinued when ALT levels exceed 3 times the upper limit.

Liver tumor risk: Long term medication users need to undergo ultrasound screening, and seek medical attention immediately if they experience abdominal pain or jaundice.

(2) Thromboembolism

Deep vein thrombosis (0.1% -1%): Avoid prolonged immobilization during medication, sudden limb swelling requires emergency treatment.

Signs of pulmonary embolism: immediate CT examination is required when experiencing difficulty breathing, chest pain, and coughing up blood.

3. Precautions for special populations

(1) Patients with depression

Emotional fluctuations increase risk: psychiatric monitoring is required, and treatment should be terminated when suicidal tendencies occur.

(2) Patients with diabetes

Deterioration of glucose tolerance: It is recommended to test HbA1c before treatment and every 3 months.

(3) Adolescent medication

Bone density impact: Calcium supplements and bone age monitoring are required if the treatment period exceeds one year.