As a compound antihypertensive drug, the side effects of valsartan and amlodipine tablets mainly involve cardiovascular system, metabolic abnormalities, and allergic reactions. The following is a classification of adverse reactions of the drug based on clinical data.

1. Adverse reactions in the cardiovascular system

(1) Common hypotensive reactions: Positional hypotension may occur, manifested as symptoms such as dizziness and fatigue.

(2) Arrhythmia: Clinical trial reports occasionally include palpitations, bradycardia, and other cardiac conduction abnormalities.

2. Metabolic abnormalities

(3) Electrolyte imbalance: Elevated blood potassium levels (related to valsartan) and hypocalcemia (related to amlodipine) can be observed.

(4) Blood glucose fluctuation: diabetes patients may have worsening blood glucose control.

3. Adverse reactions to the nervous system

(5) Headache and dizziness: The incidence rate is about 5-10%, mostly occurring in the early stages of medication.

(6) Peripheral edema: Sininidipine may cause ankle edema.

4. Digestive system reactions

(7) Gastrointestinal discomfort: including mild symptoms such as nausea and bloating.

(8) Abnormal liver function: occasional elevation of transaminases, requiring regular monitoring.

5. Allergic reactions

(9) Skin reaction: Allergic symptoms such as rash and itching may occur.

(10) Vascular edema: In severe cases, facial and laryngeal edema may occur, and medication should be stopped immediately.