Cyproterone acetate tablets (Androcur) are a classic anti-androgen therapeutic drug. Its core active ingredient is cyproterone acetate, which exerts clinical therapeutic effects primarily by blocking the biological effects of male sex hormones (androgens) and reducing the production of androgens in the body. The drug was primarily developed by Bayer AG of Germany.

1. Drug name

Cyproterone acetate tablets (brand name: ANDROCUR®)

II. Indications

Used to control excessive male sexual desire (hypersexuality) and/or abnormal sexual psychology.

When used to reduce sexual impulses associated with sexual psychological abnormalities, it should only be administered after evaluation by a doctor, provided that other intervention measures are not applicable.

III. Specifications and Characteristics

Specification: Each tablet contains 50mg or 100mg of cyproterone acetate.

Characteristics: White round tablets, 50 tablets per box.

IV. Main components

Active ingredient: Cyproterone acetate.

5. Usage and Dosage

Standard dosage: Take 1 tablet twice daily.

Dosage: Take one tablet after breakfast and dinner, accompanied by warm water.

Dose adjustment: After achieving the desired effect, the dosage can be gradually reduced, but specific details should be followed as prescribed by a doctor.

VI. Dose Adjustment and Handling of Special Situations

Missed dose: Take the missed dose immediately when remembered, and resume the regular schedule for the next dose. Do not double the dose.

Overdose: There are no reported severe cases of single overdose, but immediate consultation with a doctor is required.

Discontinuation: Do not reduce the dosage or discontinue the medication without the guidance of a doctor.

VII. Medication precautions

Dietary impact: Avoid long-term heavy drinking, as it may reduce the efficacy of the medication.

Driving and operating machinery: Fatigue and weakness may occur after taking the medication, so it is necessary to avoid related activities.

Lactose intolerance: This product contains lactose. Relevant individuals should consult a doctor before use.

VIII. Medication for special populations

Children and adolescents: Not recommended for use by individuals under 18 years of age or those with undeveloped testes and bones.

Diabetes patients: May affect blood sugar levels, requiring regular monitoring and adjustment of hypoglycemic drug dosages.

Individuals with hepatic and renal insufficiency: Use under medical supervision and regularly check liver function.

IX. Adverse reactions

Common (≥1/10): Decreased sperm count and decreased semen volume.

Relatively common (≤1/10): weight change, depression, breast tenderness, hot flushes, fatigue, shortness of breath, abnormal liver function (increased risk at high doses).

Rare (≤1/1000): rash, allergic reaction, breast lump with lactation, meningioma (with long-term or high-dose use), benign or malignant liver tumor (with extremely low risk but potentially fatal).

Other reported reactions include anemia, osteoporosis, and adrenal insufficiency (manifested as fatigue, hypotension, salt craving, etc.).

After drug withdrawal and recovery: Symptoms such as decreased sexual desire, reduced sperm count, and breast swelling are usually reversible.

X. Contraindications

Absolute taboo:

Liver diseases (including liver tumors, Dubin-Johnson syndrome, etc.);

② Any cancer other than prostate cancer;

③ Previously diagnosed with meningioma;

④ Consuming diseases (such as involuntary weight loss);

⑤ History of thrombosis or embolism;

⑥ Severe diabetes with vascular lesions;

⑦ Sickle cell anemia;

⑧ Long-term severe depression;

⑨ Hypersensitivity to cyproterone acetate or excipients;

⑩ Under the age of 18.

XI. Drug interactions

Caution is needed when combining: rifampin (anti-tuberculosis), phenytoin (anti-epileptic), St. John's wort (herbal medicine), ketoconazole/itraconazole (anti-fungal), ritonavir (anti-HIV), statin lipid-lowering drugs, and glitazone hypoglycemic drugs.

Mechanism of action: Potential for mutual interference with metabolism or exacerbation of side effects (such as statin-related muscle damage).

XII. Storage method

Keep out of direct sunlight and sealed. Store out of reach of children.

Do not use expired medications (the expiration date indicated on the packaging is up to the last day of the month).

Waste drugs are recycled through pharmacies to avoid polluting the environment.

Androcurinformation