Anastrozole is a selective nonsteroidal aromatase inhibitor that can inhibit the conversion of androstenedione produced in the adrenal gland of postmenopausal patients to estrone, thereby significantly reducing plasma estrogen levels and inhibiting breast tumor growth.

1、 Drug name

Common name: Anastrozole

Product Name: ARIMIDEX ®

2、 Indications

It is used to treat hormone receptor positive breast cancer in postmenopausal women, including the following two situations: adjuvant treatment of early breast cancer and treatment of advanced breast cancer.

3、 Specifications and characteristics

Specification: 1mg tablet

Appearance: White film coated sheet

4、 Main components

Medicinal ingredient: Anastrozole

5、 Usage and dosage

Conventional dose: once daily, 1mg (1 tablet) each time.

Dosage: Swallow the whole tablet and take it with water.

Medication time: It is recommended to take it at a fixed time every day.

Treatment course: It should be taken continuously according to the doctor's advice.

6、 Dose adjustment

Leakage handling:

Less than 12 hours before the next medication: skip missed doses.

If it is more than 12 hours before the next medication, take it immediately.

Overtreatment: Seek medical attention immediately, even if there are no symptoms, and seek timely treatment.

7、 Medication precautions

Dietary requirements: Take before or after meals unless otherwise specified.

Omission treatment: Refer to the above dosage adjustment plan.

Vomiting treatment: If vomiting occurs after taking medication, it is recommended to consult a doctor to see if additional medication is needed.

Special Reminder:

Use bubble wrap with date markings to help track medication status.

Each board contains 14 labeled tablets and 1 additional tablet, all 15 of which have the same composition.

8、 Medication for special populations

Premenopausal women: contraindicated.

Pregnant and lactating women: prohibited.

Patients with liver and kidney dysfunction: Use under close monitoring by a doctor.

Osteoporosis patients: need to assess bone risk and strengthen monitoring.

9、 Adverse reactions

Common adverse reactions:

Hot flashes, joint pain, joint stiffness, fractures.

Weakness, carpal tunnel syndrome, and skin tingling sensation.

Vaginal dryness, hair loss, rash, nausea, diarrhea.

Headache, abnormal liver function, bone pain, muscle pain.

Decreased appetite, vomiting, drowsiness/fatigue, trigger finger, high cholesterol.

Serious adverse reactions:

Depression: low mood, sleep changes, social withdrawal, etc.

Osteoporosis: Increased risk of fractures.

Ischemic heart disease: chest pain.

Hepatitis: General discomfort, jaundice.

Tendon diseases: pain, swelling.

Allergic reactions: facial swelling, difficulty breathing.

Stevens Johnson syndrome: severe skin reaction.

10、 Contraindications

Individuals who are allergic to anastrozole or any excipients.

Premenopausal women.

Pregnant and lactating women.

11、 Drug interactions

Estrogen containing drugs: may antagonize the efficacy of anastrozole.

Tamoxifen: Avoid combination use.

Herbal products containing estrogen: special attention should be paid.

12、 Storage method

Storage temperature: 15-30 ℃ room temperature environment.

Storage method: Keep the original packaging.

Caution: Keep out of reach of children and do not use expired drugs.

13、 Manufacturer

AstraZeneca Canada Inc

Important Notice:

This product may affect bone density and increase the risk of fractures. Bone density should be monitored regularly during medication. Caution should be exercised when driving or operating machinery, and related activities should be avoided if symptoms of fatigue or drowsiness occur. If any abnormal symptoms occur during medication, seek medical attention promptly.

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