Wubenmei Si is an artificially synthesized dipeptidyl aminopeptidase inhibitor with immunomodulatory and anti-tumor activities. It enhances the immune function of the body by inhibiting the activity of aminopeptidase, and is used in combination with other chemotherapy drugs for maintenance therapy after remission of acute non lymphocytic leukemia, prolonging the survival of patients.

1、 Drug name

1. Common name: Ubenimex

2. Product Name: Bestatin Capsules

3. Manufacturer: Nippon Chemical Pharmaceutical Co., Ltd

2、 Indications

Used for maintenance therapy in adult acute non lymphocytic leukemia (ANLL) after complete remission, combined with intensified chemotherapy drugs to prolong survival.

3、 Specifications and characteristics

1. Specification: 10mg per capsule.

2. Appearance: White hard capsule with white powder content.

4、 Main components

1. Active ingredients: Each capsule contains 10mg or 30mg of Ubenimex.

2. Additives: pre gelatinized starch, sucrose fatty acid esters, magnesium stearate. The capsule shell contains sodium dodecyl sulfate.

5、 Usage and dosage

1. Usually, after complete remission of adult acute non lymphocytic leukemia, maintenance and intensive chemotherapy are used in combination.

2. The regular dose of Ubenimeprazole is 30mg per day, once daily, orally. It can be adjusted appropriately according to age and symptoms.

6、 Dose adjustment

For elderly patients with generally low physiological function, special attention should be paid when using it.

7、 Medication precautions

1. Before and after meals: It is not explicitly required to take with food or after meals. It is recommended to follow medical advice.

2. Handling of missed doses: If you forget to take your medication, please consult a doctor or pharmacist as soon as possible. It is generally not recommended to take double the dose at once.

3. Vomiting treatment: If vomiting occurs after taking medication, please consult a doctor to see if additional medication is needed.

4. Medication precautions: The medication is packaged in PTP, and patients should be instructed to take it after removing it from the PTP plate to avoid swallowing PTP tablets by mistake. Accidentally swallowing may cause sharp angles to pierce the esophageal mucosa, even perforation, leading to serious complications such as mediastinitis.

8、 Medication for special populations

1. Pregnant women: Use only when the benefits of treatment outweigh the risks. There have been reports of fetal underdevelopment in animal experiments (rats).

2. Breastfeeding women: hope to avoid breastfeeding. There are reports of milk transfer in animal experiments (rats).

3. Children: Clinical trials for children have not yet been conducted.

4. Elderly people: generally have low physiological function, and should be cautious when using it.

9、 Adverse reactions

1. Below 5%: AST elevation, ALT elevation, rash, redness, itching, hair loss, nausea, vomiting, loss of appetite, abdominal pain, bloating, diarrhea, numbness, headache, dizziness, oral discomfort, edema.

2. The incidence rate is unknown: as above (the incidence rate of some adverse reactions is unknown).

10、 Contraindications

Absolute contraindications are not explicitly listed. But if there are obvious abnormalities, the medication should be stopped.

11、 Drug interactions

There is currently no apparent interaction with other drugs.

12、 Storage method

1. Storage: Store at room temperature.

2. Validity period: 3 years.

13、 Manufacturer

Manufacturing and sales: Nippon Chemical Pharmaceutical Co., Ltd.

Ubenimexinformation