Acalabrutinib is a novel oral inhibitor of Bruton tyrosine kinase (BTK), mainly used for the treatment of hematological malignancies such as chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL).

1、 Drug name

1. Common name: Acalabrutinib Capsules

2. Product Name: Calquence (Original Research Drug)

2、 Indications

Acatinib is used for the treatment of specific hematological malignancies, such as chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL)..

3、 Specifications and characteristics

Specification: 100mg/capsule.

4、 Main components

Active ingredient: Acalabrutinib.

5、 Usage and dosage

1. Conventional dose: 100mg orally, twice daily (with an interval of about 12 hours).

2. Dose adjustment: If serious adverse reactions occur (such as bleeding, infection, etc.), medication should be reduced or suspended according to the doctor's advice.

6、 Medication precautions

1. Before and after meals: It is recommended to take it at a fixed time, whether it should be taken on an empty stomach or without clear restrictions after meals.

2. Missed service: If the missed service time does not exceed 3 hours, it can be immediately replenished; If it exceeds 3 hours, skip and take the next dose according to the original plan.

3. Vomiting: Vomiting after taking medication does not require supplementation, wait for the next planned dose.

7、 Medication for special populations

1. Liver/kidney dysfunction: Use with caution, dosage may need to be adjusted.

2. Pregnant women and breastfeeding period: prohibited, may cause harm to the fetus or infant.

8、 Adverse reactions

Common adverse reactions include headache, diarrhea, fatigue, muscle pain, etc; Serious adverse reactions may include bleeding, arrhythmia, or infection.

9、 Contraindications

1. Prohibited for individuals allergic to acatinib or excipients.

2. Caution should be exercised when using potent CYP3A inhibitors/inducers in combination (which may affect efficacy or toxicity).

10、 Drug interactions

1. CYP3A inhibitors (such as ketoconazole) may increase the blood concentration of acatinib.

2. The combination of anticoagulants (such as warfarin) may increase the risk of bleeding.

11、 Storage method

Store at room temperature (20-25 ° C), avoid moisture and light.

Acalabrutinibinformation