The dosage of Bavencio varies according to the indications, mainly using a standard regimen of intravenous infusion of 800mg every 2 weeks for 60 minutes, with some cases requiring combination therapy or preoperative management. The following provides a detailed explanation of the recommended dosage and special precautions for each indication.

1. General Medication Guidelines

(1) Preoperative medication: Antihistamines and acetaminophen should be used for pre-treatment before the first 4 infusions, and adjustments should be made based on the infusion response.

(2) Standard dose: For most indications, 800mg/time is administered intravenously every 2 weeks for 60 minutes until disease progression or intolerable toxicity occurs.

2. Indicative specific dosage

(1) Merkel cell carcinoma: Single drug 800mg infused every 2 weeks, no need for combination therapy.

(2) Urethral epithelial cancer: same as Merkel cell carcinoma regimen, maintaining monotherapy mode.

(3) Renal cell carcinoma: Combination with Axitinib 5mg orally twice daily, with Axitinib increasing at discretion.

3 Special precautions

(1) Overdose treatment: There are no clear reports yet, immediate discontinuation of medication and supportive treatment are required.

(2) Dosage characteristics: Use 20mg/mL transparent solution, packaged in single dose small bottles.