As a COMT inhibitor, the side effects of Ongentys involve multiple system reactions such as cardiovascular and nervous system reactions, and special attention should be paid to drug interactions and medication adjustments for special populations.

Serious side effects that require immediate medical attention

(1) Movement disorders: manifested as uncontrollable seizures and repetitive movements, which may require adjustment of levodopa dosage.

(2) Psychological symptoms: including hallucinations, confusion, and other psychotic reactions. In severe cases, medication should be discontinued.

(3) Cardiovascular events: Combination use with catecholamines may lead to arrhythmia or severe blood pressure fluctuations.

2 Common precautions

(1) Risk of drowsiness: Caution should be exercised when driving or operating machinery, especially when combined with the use of sedatives.

(2) Positional hypotension: It is recommended to slowly change position and regularly monitor blood pressure changes.

(3) Impulsive control disorder: may manifest as pathological gambling, overeating, etc., requiring timely intervention.

3. Medication for special populations

(1) Liver dysfunction: Moderately impaired patients need to reduce their dosage, and Child Pugh grade C should be avoided.

(2) Renal insufficiency: creatinine clearance rate<30mL/min requires close monitoring.

(3) Elderly patients: The incidence of hallucinations increases in those over 70 years old and requires strengthened monitoring.

4 Key points of medication management

(1) Omission treatment: Take the medication according to the original plan the next day, no need to supplement.

(2) Discontinuation warning: Sudden cessation of medication may cause withdrawal syndrome such as high fever and confusion.

(3) Drug interactions: Combination use of non selective MAO inhibitors is prohibited.