As a plant extract preparation, special attention should be paid to dosage control, dietary taboos, and medication safety for special populations when using Evirostat (Prostate DB).

1. Precautions for routine medication

(1) Medication time: It is recommended to have a fixed daily medication time, preferably taken 1 hour before meals or 2 hours after meals.

(2) Dose control: Strictly follow the doctor's instructions for dosage, excessive dosage may cause gastrointestinal discomfort.

2 dietary taboos

(1) Avoid high-fat diet: fatty meat and fried foods may delay drug absorption.

(2) Restricting stimulating drinks: Alcohol and caffeine may exacerbate urinary frequency symptoms.

3 Pregnant women

(1) Prohibition principle: This drug has not been studied for reproductive toxicity and lacks safety data during pregnancy. Pregnant women should absolutely avoid using it.

(2) Contraceptive requirements: Women of childbearing age should take reliable contraceptive measures during medication, and stop taking medication immediately if pregnancy is detected.

4 lactating women

(1) Risk unknown: There is no research data on whether the drug is secreted through breast milk, and it is recommended to suspend breastfeeding during treatment.

(2) Resume breastfeeding: Consider resuming breastfeeding at least 48 hours after the last dose.

5 pediatric patients

(1) Age restriction: Children under 12 years old lack clinical research data and are not recommended for use.

(2) Adolescent medication: Patients aged 12-18 should use it under strict supervision of a doctor, and the dosage should be adjusted according to their weight.

6 elderly patients

(1) Dose adjustment: The starting dose for patients over 65 years old should be reduced by 25% and gradually increased according to tolerance.

(2) Monitoring focus: renal function and residual urine volume should be checked regularly to prevent urinary retention.

7 individuals with abnormal liver and kidney function

(1) Mild abnormality: No dose adjustment is required, but the follow-up interval needs to be shortened to once every 2 weeks.

(2) Moderate to severe damage: Prohibited when liver function is Child Pugh B/C grade or creatinine clearance rate is less than 30mL/min.