Syprine is a metal chelating agent used to treat Wilson's disease, an autosomal recessive genetic disorder that causes abnormal accumulation of copper in the liver, brain, and other organs.

1、 Drug name

Drug generic name: Trientine

Product Name: CUVRIOR

2、 Indications

Used to treat stable Wilson's disease adult patients who have already cleared copper and are tolerant to penicillamine.

3、 Specifications and characteristics

Specification: Each tablet contains 300 milligrams of trametine hydrochloride (equivalent to 150 milligrams of trametine)

4、 Main components

Active ingredient: Trientine hydrochloride

5、 Usage and dosage

Initial dose: Adult daily total dose of 300 milligrams to 3000 milligrams, divided into two oral doses. When converting from penicillamine to CUVRIOR, reference should be made to the dose conversion table (e.g. the original penicillamine daily dose of 125 milligrams corresponds to CUVRIOR 300 milligrams per day).

Medication time: twice a day. If the total daily dose cannot be evenly divided, the first dose should be taken in larger quantities.

6、 Dose adjustment

The dosage needs to be adjusted based on clinical evaluation and serum non ceruloplasmin copper levels. Monitor at the beginning of treatment, 3 months after treatment, and every 6 months thereafter.

7、 Medication precautions

Medication timing: It should be taken on an empty stomach (at least 1 hour before or 2 hours after meals) and at least 1 hour apart from other oral medications.

Mineral supplements: Avoid using supplements such as iron, zinc, calcium, magnesium, etc. at the same time. If iron supplementation is necessary, there should be at least a 2-hour interval between taking CUVRIOR medication.

Omission handling: Not clearly stated, it is recommended to follow medical advice.

Vomiting treatment: Not explicitly stated. If vomiting occurs after taking medication, consult a doctor.

Swallowing requirements: Swallow the whole piece, do not crush, chew or dissolve. If swallowing is difficult, the scored tablet can be broken in half and taken, but it should not be stored after being broken open.

Other: The blister pack should be opened immediately before taking the medication.

8、 Medication for special populations

Pregnant women: Copper levels should be monitored throughout the entire process and the lowest effective dose should be used. Animal experiments have shown that high doses may cause embryonic toxicity.

Breastfeeding period: The existing data does not specify whether the medication enters breast milk, and the pros and cons need to be weighed.

Children: Safety and efficacy have not been established.

Elderly people: Careful dosage selection is necessary, considering liver and kidney function as well as concomitant medication.

9、 Adverse reactions

Common adverse reactions (>5%) include abdominal pain, changes in bowel habits, rash, hair loss, and emotional fluctuations. Other possible reactions include anemia, copper/iron deficiency, allergic reactions, and the risk of worsening neurological symptoms.

10、 Contraindications

Do not use for individuals allergic to any excipients in Qu'enting or CUVRIOR.

11、 Drug interactions

Co administration with mineral supplements such as iron, zinc, calcium, and magnesium may reduce CUVRIOR absorption, and medication should be taken at strict intervals.

Take at least one hour apart from other oral medications.

12、 Storage method

Store at room temperature between 20 ° C and 25 ° C, and allow short-term storage between 15 ° C and 30 ° C.

Trientineinformation