Fluconazole (VFEND) is a broad-spectrum triazole antifungal drug that exerts antifungal activity by non competitively inhibiting fungal cytochrome P450 dependent 14 α - lanosterol demethylase, blocking ergosterol biosynthesis, and disrupting fungal cell membrane integrity.

1. Drug name

Product Name: VFEND (Fluconazole)

2. Indications

Invasive Aspergillosis

Candidiaemia in Non neutropenic Skin and Other Deep Tissue Candidal Infections in Patients with Non neutropenia

Esophageal Candidiasis

Severe fungal infections caused by Scedosporiumapiospermum and Fusarium genera (including Fusarium solani) in patients who are intolerant or ineffective to other therapies (Scedosporios and Fusarium)

3. Specifications and characteristics

Tablets: 200mg.

4. Main components

Active ingredient: Fluconazole

5. Usage and dosage

adult

Invasive aspergillosis: Take 200mg orally every 12 hours.

Candidiaemia and other deep tissue Candida infections: Take 200mg orally every 12 hours.

Scedosporiosis and Fusariosis: Take 200mg orally every 12 hours.

Esophageal candidiasis: Take 200mg orally every 12 hours.

6. Dose adjustment

Liver dysfunction: In adults with mild to moderate liver dysfunction, the maintenance dose is halved.

Renal insufficiency: In adults with moderate to severe renal insufficiency, avoid intravenous administration and consider oral administration, while closely monitoring renal function.

The dosage adjustment for pediatric and elderly patients depends on specific circumstances.

7. Medication precautions

Before and after meals: Tablets and oral suspensions should be taken at least 1 hour before or after meals.

Missed dose: Take the missed dose as soon as possible, but if it is close to the next medication time, skip the missed dose and take the medication at the regular time.

Vomiting: If vomiting occurs after taking the medication, there is no need to take it again. Continue with the next dose according to the original plan.

8. Medication for special populations

Pregnant women: May cause harm to the fetus, risks and benefits should be evaluated before use.

Breastfeeding women: It is not yet clear whether it is secreted into breast milk. It is recommended to suspend breastfeeding during medication.

Children: The safety and effectiveness of children under 2 years old have not yet been established.

Elderly: No need to adjust dosage according to age, but close monitoring of adverse reactions is necessary.

9. Adverse reactions

Common adverse reactions include visual impairment, fever, nausea, rash, vomiting, chills, headache, abnormal liver function, tachycardia, hallucinations, etc.

Serious adverse reactions include liver toxicity, arrhythmia and QT interval prolongation, infusion related reactions, severe skin reactions, photosensitivity, adrenal insufficiency, etc.

10. Contraindications

Individuals allergic to fluconazole or any excipients.

It is prohibited to use it in combination with drugs such as pimozide, quinidine, sirolimus, rifampicin, carbamazepine, long-acting barbiturates, efavirenz, ritonavir, rifampicin, ergot alkaloids, St. John's wort, naloxone alcohol, tofacitant, lurasidone, and Veneto (in specific cases).

11. Drug interactions

Voriconazole is a strong inhibitor of CYP3A4, CYP2C9, and CYP2C19, which can increase the plasma concentration of drugs metabolized by these enzymes.

Simultaneously using CYP3A4, CYP2C9, and CYP2C19 inducers can significantly reduce the plasma concentration of voriconazole.

12. Storage method

Tablets: Store at 15 ° C to 30 ° C (59 ° F to 86 ° F).

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