Voriconazole (Vfend) is a broad-spectrum triazole antifungal drug mainly used to treat severe fungal infections such as invasive aspergillosis. Special attention should be paid to liver function monitoring and drug interactions when using it. The following provides a detailed explanation from two aspects: indications and medication precautions.

1. Indications

(1) Invasive aspergillosis

Fluconazole is a first-line treatment for invasive aspergillosis, with a clinical remission rate of 50-60%, significantly better than traditional amphotericin B.

(2) Candida infection

Effective against fluconazole resistant candidemia, especially infections caused by Candida albicans and Candida albicans.

(3) Other fungal infections

It can be used for the treatment of rare fungal infections such as Fusarium and Clostridium perfringens, as well as for the prevention of fungal infections in immunocompromised patients.

2. Medication precautions

(1) Liver function monitoring

Regular monitoring of liver function is necessary during treatment, and medication should be discontinued if transaminase levels exceed 5 times the normal range.

(2) Drug interactions

The combination of drugs such as rifampicin and carbamazepine can reduce blood drug concentration, and the dosage needs to be adjusted.

(3) Medication for special populations

Children should adjust their dosage according to their weight, pregnant women should avoid using it, and elderly people should use it with caution and monitor for adverse reactions.

(4) Adverse reaction management

Common visual impairments, rashes, and other reactions are usually reversible; Severe skin reactions require immediate discontinuation of medication.

(5) Medication regimen

On the first day, the dosage should be loaded, and intravenous and oral preparations can be used interchangeably, but attention should be paid to the difference in bioavailability.