Meloxicam is a nonsteroidal anti-inflammatory drug that exerts analgesic, anti-inflammatory, and antipyretic effects by inhibiting cyclooxygenase (COX-1 and COX-2) and reducing prostaglandin synthesis.

1、 Drug name

1. Product Name: MOBIC

2. Common name: Meloxicam tablets

2、 Indications

This product is suitable for:

1. Relief symptoms of osteoarthritis.

2. Relief symptoms of rheumatoid arthritis.

3. Used for relieving symptoms of juvenile rheumatoid arthritis with few joints and multiple joints in pediatric patients weighing no less than 60 kilograms.

3、 Specifications and characteristics

15mg tablets.

4、 Main components

Active ingredient: Meloxicam.

5、 Usage and dosage

1. Key principle: Use the lowest effective dose and minimize the duration of treatment as much as possible.

2. Osteoarthritis and rheumatoid arthritis: The initial dose is once daily, 7.5mg each time. Some patients may benefit from increasing to once daily, 15mg each time.

3. Juvenile rheumatoid arthritis (weight not less than 60 kg): once daily, 7.5mg each time. Clinical studies have shown that increasing the dose does not provide additional benefits.

4. Usage: Once a day, can be taken with food or on an empty stomach.

6、 Dose adjustment

1. Renal injury:

Mild to moderate kidney injury: No dose adjustment required.

Severe kidney injury: Not recommended for use.

Hemodialysis patients: The maximum daily dose is 7.5mg. Meloxicam cannot be cleared by dialysis.

2. Liver injury:

Mild to moderate liver injury: No dose adjustment required.

Severe liver injury: not fully studied, should be used with caution.

7、 Medication precautions

1. Meal/fasting: can be taken with food or on an empty stomach.

2. Important reminder: Meloxicam tablets cannot be interchanged with other oral Meloxicam preparations, even if the milligram strength is the same, as it may result in different systemic exposures.

3. Omission handling: Not explicitly mentioned in the prescription information. If missed, it is recommended to take it as soon as possible; If it is close to the next medication time, skip the missed dose and take the next dose at the normal time. Do not take double the dose at once.

8、 Medication for special populations

1. Pregnancy:

About 20 to 30 weeks: Use the lowest effective dose and shortest duration only when necessary. If the treatment exceeds 48 hours, ultrasound monitoring of amniotic fluid volume should be considered.

About 30 weeks and later: Avoid use as it may cause premature closure of the fetal ductus arteriosus and/or oligohydramnios/neonatal renal dysfunction.

2. Breastfeeding: It is not yet clear whether it is secreted through human milk. The benefits of breastfeeding, the mother's demand for medication, and the potential risks of medication to the infant should be considered comprehensively.

3. Children: Safety and efficacy have been evaluated in patients with rheumatoid arthritis aged 2 to 17 years old. Children under 2 years old have not been studied yet.

4. Older adults: Compared to younger patients, they are at a higher risk of experiencing severe cardiovascular, gastrointestinal, and renal adverse reactions. Medication should start at the lower end of the recommended dosage range and be closely monitored.

9、 Adverse reactions

1. Common adverse reactions (incidence rate not less than 5% and higher than placebo): diarrhea, upper respiratory tract infection, indigestion, flu like symptoms.

2. Common adverse reactions in pediatric patients include abdominal pain, vomiting, diarrhea, headache, and fever (with a higher incidence than in adults).

3. Serious adverse reactions:

Cardiovascular risk: increases the risk of severe cardiovascular thrombotic events (such as myocardial infarction, stroke), which may be fatal. Coronary artery bypass grafting is contraindicated during the perioperative period.

Gastrointestinal risk: increases the risk of serious gastrointestinal adverse events (such as bleeding, ulcers, perforation), which may be fatal.

4. Other serious adverse reactions: hepatotoxicity, hypertension, heart failure and edema, nephrotoxicity and hyperkalemia, severe skin reactions (such as Stevens Johnson syndrome, toxic epidermal necrolysis), DRESS syndrome, fetal toxicity, anemia, and bleeding events.

10、 Contraindications

1. Individuals who are allergic to meloxicam or any excipients.

2. Patients with a history of asthma, urticaria, or other allergic reactions induced by aspirin or other nonsteroidal anti-inflammatory drugs.

3. Perioperative period of coronary artery bypass grafting.

11、 Drug interactions

1. Anticoagulants/antiplatelet drugs: Combination with warfarin, aspirin, selective serotonin reuptake inhibitors, etc. increases the risk of bleeding and requires monitoring for signs of bleeding.

2. Aspirin: It is not recommended to use it in combination with nonsteroidal anti-inflammatory drugs (caution should also be exercised with lower doses of aspirin used for cardiovascular protection), as it increases gastrointestinal toxicity.

3. Angiotensin converting enzyme inhibitors/angiotensin receptor antagonists/beta blockers: may reduce the antihypertensive effect; Co administration in elderly, hypovolemic, or renal insufficiency patients may lead to deterioration of renal function.

4. Diuretics: May reduce the sodium excretion and antihypertensive effects of furosemide and thiazide diuretics.

5. Lithium supplements: Increase plasma lithium levels and monitor for signs of lithium toxicity.

6. Methotrexate: May increase the toxicity of methotrexate.

7. Cyclosporine: May increase the nephrotoxicity of cyclosporine.

8. Other nonsteroidal anti-inflammatory drugs or salicylates: Not recommended for combination as they increase gastrointestinal toxicity and have no improvement in efficacy.

9. Pemetrexed: May increase bone marrow suppression, renal and gastrointestinal toxicity associated with Pemetrexed.

12、 Storage method

1. Store at room temperature ranging from 20 ° C to 25 ° C (68 ° F to 77 ° F); Allow brief fluctuations to 15 ° C to 30 ° C (59 ° F to 86 ° F).

2. Store in a dry place and use a tight container for preservation.

3. Please keep it out of reach of children.

Meloxicaminformation