Estradiol heptanoate is a long-acting estrogen preparation mainly used as a substitute therapy for endogenous estrogen deficiency related diseases.

1、 Drug name and manufacturer

1. Drug name: estradiol heptanoate injection, trade name Progynon Depot.

2. Manufacturer: manufactured and sold by FujiPharma Co., Ltd.

2、 Indications

This product is mainly used to treat diseases related to estrogen deficiency:

1. Amenorrhea (absence of menstruation).

2. Uterine hypoplasia.

3、 Specifications and characteristics

1. Specification: 1mL per ampoule, containing 10mg of active ingredient.

2. Characteristic: This product is an injection solution, and its active ingredient is estradiol valerate ester (a long-acting ester of estradiol).

4、 Main components

1. Active ingredient: estradiol valerate ester.

2. Physical and chemical properties: white crystalline or crystalline powder, odorless. Easy to dissolve in ethanol, almost insoluble in water.

5、 Usage and dosage

1. Conventional dose: calculated as estradiol valerate ester, adults usually take 5-10mg each time, once every 1-4 weeks, administered by intramuscular injection.

2. Dose adjustment: It can be adjusted according to the patient's symptoms.

6、 Medication precautions

1. Administration method: This product is an oily injection and is only for intramuscular injection. Avoid nerve running areas. If there is severe pain or bleeding during injection, the needle should be immediately removed and replaced.

2. Injection frequency: Repeated injections at the same site should be avoided.

3. The impact on menstrual cycle: Medication should be avoided at times that may interfere with normal physiological menstrual flow.

4. Requirement for avoiding pregnancy: For patients without menstruation or uterine hypoplasia, effective non hormonal contraceptive methods (excluding safe period methods) must be used during treatment. If menstrual bleeding occurs, pregnancy should be considered and medication should be discontinued before diagnosis.

5. Leakage treatment: This product is a long-acting injection, usually administered by medical staff in medical institutions, and there is no problem of daily leakage in patients.

6. Vomiting treatment: This product is an injection and there is no vomiting or absorption problem with oral medication.

7、 Medication for special populations

1. Pregnant women: Pregnant women or women who may become pregnant are prohibited from using it. Animal experiments have shown that estrogen can cause reproductive tract cancer in offspring.

2. Breastfeeding women: weigh the pros and cons before deciding whether to use medication or breastfeed. It is known that drugs can enter the milk of healthy women.

3. Children: For patients with incomplete bone development and pre puberty, it may lead to early closure of epiphyseal plates or precocious puberty, and should be used with caution.

4. Elderly people: Physiological functions usually decline and medication should be taken under the guidance of a doctor.

5. Patients with liver dysfunction: It is contraindicated for patients with severe liver dysfunction. Patients with general liver disease may experience worsening symptoms and should use with caution.

6. Patients with renal function damage: may cause sodium or body fluid retention, which should be used with caution.

7. Postoperative and long-term bedridden patients: increased blood coagulation and increased risk of cardiovascular side effects.

8、 Adverse reactions

1. Major side effects: Long term continuous use may cause thrombosis.

2. Allergic reactions: Allergic symptoms may occur.

3. Mental nervous system: may lead to the recurrence of mental disorders and headaches.

4. Electrolyte metabolism: Hypercalcemia, sodium and fluid retention may occur.

5. Reproductive system: There may be withdrawal bleeding, irregular bleeding, and changes in menstrual blood volume.

6. Breasts: There may be breast pain and a feeling of breast fullness.

9、 Contraindications

1. Patients with or suspected of estrogen dependent malignancies (such as breast cancer and endometrial cancer).

2. Patients with a history of breast cancer.

3. Untreated patients with endometrial hyperplasia.

4. Patients with thrombophlebitis, pulmonary embolism, or a history of the disease.

5. Arterial thromboembolic diseases (such as coronary heart disease, stroke) or those with a history of the disease.

6. Patients with severe liver dysfunction.

7. Patients with unexplained abnormal genital bleeding.

8. Pregnant or potentially pregnant women.

10、 Drug interactions

Combination with hypoglycemic drugs: This product may reduce the effects of insulin, sulfonylurea, and biguanide hypoglycemic drugs. When used together, blood glucose should be closely monitored and the dosage of hypoglycemic drugs should be adjusted as needed.

11、 Storage method

1. Storage conditions: It should be stored at room temperature.

2. Validity period: The validity period is 5 years.

12、 Important Warning and Precautions

1. Long term medication risk: long-term use of estrogen for hormone supplementation may increase the risk of endometrial cancer, breast cancer, coronary heart disease, stroke and dementia. The risk is related to the duration of use, and patients should be informed of the pros and cons, and the minimum effective dose should be used to avoid long-term abuse.

2. Regular check ups: Breast and gynecological examinations should be conducted regularly before and during treatment.

Progynon-Depotinformation