The usage and dosage of Enasidenib should strictly follow the standard protocol, while paying attention to specific food taboos to avoid drug interactions. The following provides a detailed explanation from three aspects: administration plan, dosage adjustment, and dietary taboos, to ensure the maximum safety and efficacy of medication.

1. Usage and dosage

(1) Standard dose: It is recommended to take 100mg orally once a day, whole tablets should be swallowed, and should not be crushed or chewed.

(2) Medication time: It is recommended to take it at a fixed time (such as after breakfast), on an empty stomach or with meals, but consistency should be maintained.

(3) Omission treatment: If the missed dose exceeds 12 hours, skip the daily dose and continue to administer according to the original plan the next day; You can take it immediately within 12 hours.

2. Adjustment for special populations

(1) Liver dysfunction: Mild to moderate damage does not require adjustment, severe (Child Pugh C grade) is contraindicated.

(2) Renal insufficiency: Mild to moderate, no adjustment needed. Use with caution in patients with end-stage renal disease or dialysis due to insufficient data.

(3) Elderly patients: those aged 65 and above do not need adjustment, but need to strengthen adverse reaction monitoring.

3. Forbidden foods

(1) Grapefruit/grapefruit: may inhibit CYP3A4 metabolic enzymes, increase drug blood concentration and toxicity risk.

(2) High fat diet: may delay drug absorption, it is recommended to avoid taking with high-fat foods.

(3) Alcohol: It may increase the burden on liver function, especially for patients with liver dysfunction who should strictly abstain from alcohol.