Acofide, as a medication for the digestive system, primarily induces side effects related to the gastrointestinal tract and central nervous system. Most of these symptoms are mild and can resolve spontaneously. However, it is crucial to be vigilant about severe adverse reactions and take timely intervention measures. During medication, relevant indicators need to be monitored regularly, and medication regimens should be adjusted for special populations.

1. Common self-relievable side effects

Symptoms such as dry mouth, loss of appetite, and diarrhea are mostly transient reactions that can be alleviated by drinking water in small amounts but frequently, and adjusting the diet structure. For symptoms like dizziness or fatigue, it is recommended to avoid driving or working at heights, and usually, one can adapt to these within 1-2 weeks.

2. Severe side effects requiring medical intervention

(1) Abnormal liver function

If jaundice occurs or the urine color deepens, the medication should be discontinued immediately. ALT/AST levels should be monitored monthly before treatment and during the medication period. Patients with concurrent liver disease should have a reduced dosage.

(2) Anaphylactic reaction

Skin itching, urticaria, etc. require antihistamine treatment. In the event of immediate allergic reactions such as facial swelling or breathing difficulties, the medication should be discontinued immediately and emergency treatment should be sought.

3. Management of adverse reactions in the nervous system

If experiencing headaches or insomnia, the medication time can be adjusted to the morning. If extrapyramidal symptoms such as tremors or confusion occur, the medication should be discontinued and a neurology consultation is required.

4. Special medication precautions

The initial dosage for elderly patients should be halved, and the dosage interval needs to be adjusted for those with renal insufficiency. Alcohol consumption is prohibited during medication to avoid exacerbating central inhibition.

5. Prevention of drug interactions

Avoid combining with anticholinergic drugs as it may exacerbate constipation. When used in combination with CYP3A4 inhibitors, monitor for adverse reactions and adjust the dosage if necessary.