Metirapone is mainly used for the diagnosis and treatment of Cushing's syndrome, and its side effects involve multiple systems, but most can be alleviated through appropriate measures. The following text will provide a detailed explanation of common side effects and corresponding mitigation methods to help patients safely take medication.

1. Common side effects and mitigation methods

(1) Gastrointestinal reactions: Nausea, vomiting, or abdominal pain may occur. It is recommended to take it with food and administer it in small doses to alleviate symptoms. If the condition persists and does not improve, medical attention should be sought to adjust the dosage.

(2) Dizziness and drowsiness: Central nervous system suppression is more common. During medication, avoid driving or operating machinery, and if necessary, adjust the medication time to the evening.

(3) Skin rash allergy: If there is itching or redness on the skin, the medication should be stopped immediately and antihistamines should be taken. Severe allergies require emergency treatment.

2. Serious side effects to be wary of

(1) Adrenal insufficiency: Long term use may inhibit adrenal cortex function. Regularly monitor cortisol levels and supplement with glucocorticoids if necessary.

(2) Hypotension risk: This medication may cause a decrease in blood pressure. During medication, blood pressure should be monitored to avoid sudden changes in position, especially for the elderly.

3. Special precautions

(1) Drug interactions: Avoid combining with barbiturates, rifampicin, and other liver enzyme inducers as it may affect drug efficacy. Combination medication requires consultation with a doctor.

(2) Monitoring requirements: During the treatment period, it is necessary to regularly check electrolyte and adrenal function, and adjust the treatment plan based on the results.

(3) Pregnant women should not use it: it may affect the development of fetal adrenal glands. Women of childbearing age should ensure that contraceptive measures are in place when using it.