Attention should be paid to local and systemic risks when using Opzelura cream, including skin reactions, infection risks, and medication requirements for special populations. The following provides a detailed explanation of precautions in terms of usage standards, monitoring points, and contraindications.

1. Usage Standards

(1) Dosage control: For external use only. Adults and adolescents over 12 years old should take twice a day, with a single dose not exceeding 20% of their body surface area.

(2) Medication site: Avoid contact with mucous membranes such as eyes, mouth, and nose. Wash hands after medication to prevent accidental contact.

2 Adverse reaction monitoring

(1) Skin reaction: If severe itching, burning sensation, or worsening redness occurs, medication should be suspended and medical evaluation should be sought.

(2) Signs of infection: Monitor for symptoms of herpes zoster and other infections, especially for those with a history of immunodeficiency who need to be vigilant.

3 Precautions for Special Groups

(1) Pregnancy and lactation: Animal studies have shown potential fetal risks, and are contraindicated during pregnancy. Breastfeeding or medication should be stopped during lactation.

(2) Abnormal liver function: Patients with moderate to severe liver damage should use it with caution. It is recommended to adjust the frequency of medication and monitor liver function.

4 Drug Interactions

(1) Immunosuppressants: Combination with systemic JAK inhibitors may enhance immunosuppressive effects and should be avoided.

(2) Live vaccination: Avoid receiving live vaccines during treatment as it may reduce vaccine efficacy or increase the risk of infection.

5 Storage and Handling

(1) Storage conditions: Keep the original packaging in an environment of 20-25 ℃ to avoid drug denaturation caused by freezing or high temperature.

(2) Disposal: Unused ointment should be disposed of as medical waste to prevent accidental contact by children or pets.