Targeted management is necessary for joint pain, nausea, and photosensitive reactions that may occur during treatment with Encorafenib. Joint pain can be relieved through medication adjustment and non medication intervention; Nausea is recommended to be administered in multiple doses and combined with antiemetic drugs; The photosensitive reaction requires strict sun protection. The following provides a detailed explanation of coping strategies from three aspects: symptom characteristics, treatment measures, and precautions.

Joint pain management

Joint pain is a common side effect of Conafenib, characterized by joint stiffness, swelling, or limited mobility. Usually occurring in the early stages of treatment, it may be related to drug inflammation response.

(1) Non pharmacological intervention

It is recommended to exercise with moderate joint activity and avoid maintaining the same posture for a long time. It can be supplemented with hot or cold compress to relieve local symptoms, and wearing supportive protective gear to reduce joint burden.

(2) Drug intervention

Mild pain can be treated with acetaminophen; Moderate to severe pain requires assessment of whether adjustments to the dose of conafenib are necessary. If there is no improvement for 2 weeks, medication should be suspended until symptoms improve.

2 Nausea control

Nausea often occurs 1-2 hours after medication and may be accompanied by decreased appetite. Related to the stimulation of gastrointestinal mucosa or central nervous system by drugs.

(1) Adjustment of administration method

It is recommended to take the medication with meals or in divided doses (such as half in the morning and half in the evening). Avoiding high-fat diets and having small and frequent meals can alleviate symptoms. After vomiting, there is no need to take the next dose according to the original plan.

(2) Application of antiemetic drugs

Prophylactic use of 5-HT3 receptor antagonists (such as ondansetron). If the vomit contains blood or appears as coffee grounds, seek medical attention immediately to rule out gastrointestinal bleeding.

3. Protection against photosensitive reactions

The photosensitive reaction manifests as skin erythema, burning sensation, or flaking, with an incidence rate of about 30%. Related to the increase in skin sensitivity to ultraviolet radiation caused by medication.

(1) Sunscreen measures

During treatment, it is necessary to use broad-spectrum sunscreen with SPF ≥ 30 and wear a sun hat/clothing. Avoid going out during the strong ultraviolet period from 10:00-16:00, and the car windows should be covered with anti ultraviolet film.

(2) Skin care

When redness and swelling occur, topical corticosteroid ointment can be applied. If it develops into a grade 3 skin reaction (painful desquamation affecting daily life), medication should be temporarily discontinued until recovery.

(3) Dose adjustment

Recurrent grade 2 or first-time grade 3 photosensitive reactions require a reduction of 25% -50%; Level 4 reaction requires permanent discontinuation of medication. Regular dermatological follow-up during treatment.