Proper use of Avatrombopag is the foundation for ensuring therapeutic efficacy. The following provides a concise guide on the administration method, dosage adjustment, and management of missed doses.

1、 Fasting or with meals?

1. It is recommended to take it with meals

Avatranib should be taken with food to reduce stomach discomfort and improve the stability of drug absorption.

2. Fixed daily time

Taking it with meals at the same time every day can help maintain a stable blood drug concentration and avoid the impact of time fluctuations on efficacy.

3. Avoid consuming high calcium foods together

During medication, it is advisable to avoid consuming high calcium foods (such as milk and calcium tablets) in large quantities, as this may affect drug absorption. At least 2 hours apart.

2、 How to adjust the dosage?

1. Initial dose and treatment course

The initial dose is determined by the doctor based on platelet count and indications. The usual course of treatment for patients with chronic liver disease is once daily for 5 consecutive days.

2. Monitor platelet adjustment

During the treatment period, it is necessary to regularly check the platelet count. The doctor will adjust the subsequent medication plan based on the platelet response and cannot increase or decrease the dosage on their own.

3. Indications for discontinuation of medication

If the platelet count reaches the target value or serious adverse reactions occur, the doctor may recommend suspending or terminating the medication, and strict adherence to medical advice is required.

3、 How to deal with missed services?

On the day of missed service

If a missed dose is found on the same day, it should be replenished as soon as possible (with meals). If it is less than 6 hours before the next medication, skip the missed dose and take the next dose on time.

2. Prohibition of double dosage

Do not take double doses to make up for missed doses, as this increases the risk of adverse reactions without any additional benefits.

3. Recording and Reminders

It is recommended to use medication boxes or mobile alarm clocks to remind daily medication intake. If the medication is frequently missed, it is necessary to communicate with the doctor in a timely manner to assess whether the medication plan needs to be adjusted.