During the treatment with Abexili, it is important to pay close attention to four potential risks: diarrhea, liver injury, decreased blood cells, and thrombosis. Proactive monitoring and timely response are the core of ensuring medication safety.

1. Diarrhea management

1.1 Timely fluid replacement

Prefer oral rehydration salts or diluted salt water, and avoid high sugar beverages. If diarrhea occurs more than 6 times within 24 hours, or if bloody stools or severe abdominal pain occur, contact a doctor immediately.

1.2 Diet and Medication

Use a low fiber, easily digestible diet (such as porridge and bananas) to avoid greasy and spicy food. Loperamide and other antidiarrheal drugs should be used under the guidance of a doctor.

2. Liver toxicity monitoring

2.1 Regular testing

During the initial stage of medication, liver function should be monitored every two weeks, and the interval can be extended once it stabilizes. If the transaminase is significantly elevated, medication should be suspended or the dosage should be reduced.

2.2 Symptom recognition

When there is yellowing of the skin or sclera, darkening of urine color, upper right abdominal pain, or severe fatigue, it should be considered an alarm and medical attention should be sought immediately.

3. Prevention of bone marrow suppression

3.1 Blood routine monitoring

Recheck the whole blood count at least once a month. When the absolute value of neutrophils is below 1.0 × 10 ⁹/L, it is necessary to discuss with a doctor to suspend or adjust the dosage.

3.2 Prevention of Infection

During periods of low white blood cell count, wash hands frequently, avoid raw food, and stay away from crowded places. If the body temperature is ≥ 38.3 ℃, seek medical attention as soon as possible.

4. Identification of Thrombosis Risk

4.1 Seek medical attention promptly

If there is unilateral limb swelling, pain, chest pain, sudden difficulty breathing or hemoptysis, emergency medical attention should be sought, which may indicate deep vein thrombosis or pulmonary embolism.

4.2 Risk Assessment

Individuals with a history of thrombosis, obesity, or long-term bed rest should proactively inform their doctors to assess the necessity of preventive anticoagulation.