During the treatment of Besudil, special attention should be paid to infection, hepatotoxicity, and drug interactions. Standardized monitoring and rational drug use are key to reducing risks.

1、 Risk of infection

Besudil may increase the risk of infection. During treatment, pay attention to personal hygiene and wash hands frequently.

Avoid contact with people with colds, fever, or other infections.

Avoid raw and undercooked food to prevent gastrointestinal infections.

If there are signs of infection such as fever, sore throat, cough, or redness and swelling of the wound, seek medical attention immediately.

Do not use anti infective drugs on your own and follow medical advice.

2、 Hepatotoxicity

Regular monitoring of liver function, including transaminase and bilirubin, is required during treatment.

If you experience fatigue, decreased appetite, darkened urine color, or yellowing of the skin, please inform the doctor promptly.

Avoid drinking alcohol and reduce liver burden.

Avoid using other drugs or herbs that may damage the liver.

When liver function is abnormal, doctors may suspend medication, reduce dosage, or permanently stop medication.

3、 Drug interactions

Avoid co administration with strong CYP3A inducers as it may reduce the efficacy of besudil.

Co administration with strong CYP3A inhibitors may increase drug exposure and require monitoring for adverse reactions.

Notify the doctor of all concomitant medications, including prescription drugs, over-the-counter drugs, and herbal medicines.

Avoid taking supplements that affect liver enzymes, such as St. John's wort, on your own.

Any dosage adjustment must follow the doctor's advice and cannot be adjusted or stopped on one's own.

4、 Common precautions

Regular follow-up visits, complete blood routine, liver function tests, and other examinations.

Record medication and symptom changes for easy evaluation by doctors.

If severe discomfort occurs, seek medical attention immediately.