He specifically activates TRH receptors in the central nervous system for taltirelin, promoting the release and metabolism of neurotransmitters such as acetylcholine and dopamine, enhancing nerve conduction function, and improving motor dysfunction symptoms in patients with spinocerebellar degeneration.

1、 Drug name

1. Common name: Tartirelin Hydrogen

2. Product Name: Cerecit 5mg/Cerecit OD 5mg

3. English name: TaltirelinHydrorateTablets

2、 Indications

Used to improve motor disorders caused by spinocerebellar degeneration.

3、 Specifications and characteristics

1. Specification: Each tablet contains 5mg of Tatirelin hydrate.

2. Appearance: Tablets,

4、 Main components

Active ingredient: Tetracycline hydrate (5mg per tablet).

5、 Usage and dosage

1. Adult standard dosage: 5mg each time, twice a day (orally after breakfast and dinner).

2. Dose adjustment: It can be adjusted appropriately according to age and symptoms.

6、 Dose adjustment

1. Patients with renal insufficiency: Severe renal insufficiency may increase blood drug concentration by about 4.2 times, and caution should be exercised when using medication.

2. Elderly people: Due to possible decline in kidney function, it is easy to cause sustained high blood drug concentrations, and should be used with caution and pay attention to dosage.

3. Children: There is currently no clinical research data available.

7、 Medication precautions

1. Before or after meals: It is recommended to take after meals as the postprandial blood drug concentration (Cmax and AUC) is significantly reduced compared to fasting.

2. Omission handling: Not clearly stated, it is recommended to follow the principle of regular supplementation, and skip if it is close to the next medication time.

3. Supplementing after vomiting: Not specified, it is recommended to consult a physician.

4. Precautions for OD film:

Not suitable for automatic charter flights.

It should be taken immediately after removal from the PTP board to avoid moisture absorption.

It can be taken with or with water, but should not be taken in bed.

If there is a defect, the full dose should still be taken.

8、 Medication for special populations

1. Pregnant women: Use only when the benefits outweigh the risks.

2. Breastfeeding women: It is recommended to stop breastfeeding as animal experiments have shown that drugs can enter breast milk.

3. Children: Safety has not been established.

4. Elderly people: Use medication with caution and pay attention to dosage.

9、 Adverse reactions

1. Serious adverse reactions:

Spasms (<1%)

Malignant syndrome (<1%, characterized by fever, muscle stiffness, tachycardia, etc.).

Liver dysfunction and jaundice (<1%).

Shock like symptoms (frequency unknown).

Thrombocytopenia (frequency unknown).

2. Other common adverse reactions (0.1% -5%):

Digestive system: nausea, vomiting, diarrhea, loss of appetite, stomach discomfort.

Nervous system: headache, dizziness, tremors, drowsiness.

Abnormal laboratory indicators: AST, ALT, γ - GTP elevation, etc.

3. Other: rash, TSH fluctuations, CK elevation, etc.

10、 Contraindications

At present, there are no specific contraindications listed for this drug, but it should be used under the guidance of a physician based on the patient's specific condition (such as allergy history, severe renal dysfunction, etc.).

11、 Drug interactions

It is recommended to pay attention to monitoring when combining medications, especially those that affect thyroid function or the central nervous system.

12、 Storage method

1. Store at room temperature and avoid moisture.

2. PTP packaging should be moisture-proof after opening.

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