Tatirelin tablets are an oral neuromodulatory drug, mainly composed of Tatirelin hydrate, which belongs to the class of thyroid stimulating hormone releasing hormone (TRH) receptor agonists.

1、 Drug name

Product Name: Sereist Tablets/Oral Disintegrating Tablets

Common name: Taltirelin

2、 Indications

Used to improve motor dysfunction symptoms caused by spinocerebellar degeneration.

3、 Specifications and characteristics

Specification: 5mg/tablet (including 5mg of Tatirelin hydrate).

Appearance: Capsule.

4、 Main components

Active ingredient: Japanese Pharmacopoeia's Tatirelin Hydrate (5mg/tablet).

5、 Usage and dosage

Adult standard dose: 5mg each time, twice a day (once in the morning and once in the evening).

Medication time: Take orally after meals.

Formulation selection:

Ordinary films need to be served with water.

6、 Dose adjustment

The dosage should be adjusted appropriately according to age and symptoms.

Elderly people need to pay special attention to dosage adjustment (as kidney function may decrease).

Patients with severe renal insufficiency need to adjust the dosage (plasma concentration may increase by about 4.2 times).

7、 Medication precautions

Before and after meals: It is recommended to take it after meals (blood drug concentration is higher when taken on an empty stomach).

Handling of missed services: Unless otherwise specified, it is recommended to follow the principle of regular replacement services.

Vomiting treatment: Not clearly stated, it is recommended to consult a physician.

Other precautions:

PTP packaging should be taken out before consumption to prevent accidental ingestion of the packaging.

Oral disintegrating tablets should be taken out before consumption to avoid moisture absorption.

When oral disintegrating tablets have defects, they should still be taken in full.

Bedridden patients are not allowed to use anhydrous medication.

8、 Medication for special populations

Pregnant women: Use only when the benefits outweigh the risks.

Breastfeeding period: It is recommended to stop breastfeeding (animal experiments have shown that drugs can enter breast milk).

Children: No clinical trials have been conducted, and safety has not been established.

Elderly people: Pay attention to dosage and monitor kidney function.

Renal insufficiency: In severe cases, the dosage needs to be adjusted.

Patients with endocrine disorders: Hormone levels (TSH, prolactin, etc.) need to be monitored.

9、 Adverse reactions

Serious adverse reactions:

Convulsions (<1%).

Malignant syndrome (<1%): manifested as fever, muscle stiffness, and increased heart rate.

Liver dysfunction and jaundice (<1%).

Shock like symptoms (frequency unknown).

Thrombocytopenia (frequency unknown).

Common adverse reactions (0.1-5%):

Digestive system: nausea, vomiting, diarrhea, loss of appetite.

Nervous system: headache, dizziness, tremors, drowsiness.

Circulating system: palpitations, blood pressure fluctuations.

Other: rash, thyroid hormone changes, CK elevation, etc.

10、 Contraindications

The contraindications are not explicitly listed, but they are prescription drugs that must be used with a physician's prescription.

11、 Drug interactions

No specific drug interactions have been specified.

Attention should be paid to the combination with other drugs that affect the central nervous system.

12、 Storage method

Store at room temperature.

After opening, it should be stored against moisture.

Validity period: 3 years.

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