Delamanid may cause discomfort such as nausea, headache, and insomnia when treating multidrug-resistant tuberculosis. Scientifically managing these side effects can help improve patients' medication adherence.

I. Strategies for Managing Nausea

1. Adjust dietary habits

Nausea is often related to taking the medication. Patients are advised to strictly take Delamanid with meals and avoid taking it on an empty stomach. They may eat smaller, more frequent meals and choose light, easily digestible foods, avoiding greasy and spicy irritants.

2. Pay attention to hydration and rest

If nausea occurs after taking the medication, patients may drink an appropriate amount of warm water, but should avoid drinking large amounts of water, which may increase the burden on the stomach. After taking the medication, maintain a sitting or semi-reclining position for rest, and avoid lying down immediately.

3. Seek timely medical evaluation

If nausea continues to worsen, leading to frequent vomiting or inability to eat, patients should contact a physician to assess whether the medication regimen needs adjustment or whether antiemetic drugs should be added. Do not discontinue the medication on your own.

II. Methods for Relieving Headache

1. Ensure adequate rest

When headache occurs, patients should rest as much as possible in a quiet environment with soft lighting and avoid stimulation from strong light and noise. Maintain a regular daily routine and avoid excessive fatigue.

2. Appropriate physical relief

Patients may try applying a warm towel to the forehead or gently massaging the temples to help relax. Avoid taking over-the-counter painkillers on your own, especially drugs that may affect liver function; consult a physician first.

3. Monitor blood pressure and symptoms

Some headaches may be related to blood pressure fluctuations. If the headache is severe, persists without relief, or is accompanied by symptoms such as blurred vision or vomiting, seek medical attention immediately to identify the cause.

III. Measures to Improve Insomnia

1. Adjust medication timing

If insomnia is related to evening medication, under the physician's guidance, assess whether the time of the last dose can be appropriately moved earlier, but it must be ensured that the drug is taken with meals. Do not change the regimen on your own.

2. Establish good sleep habits

Avoid using electronic devices before bedtime and reduce intake of caffeine and strong tea. Keep the bedroom environment quiet and dim, and try soaking feet in warm water or listening to soft music to relax body and mind.

3. Avoid excessive anxiety

Some insomnia stems from worry about the disease. Patients may communicate with family members or healthcare professionals to relieve psychological stress. If insomnia seriously affects daily life, inform the physician to assess whether intervention is needed.

4. Be alert to serious reactions

If insomnia is accompanied by psychiatric symptoms such as palpitations, abnormal mood fluctuations, or hallucinations, report to the physician immediately to determine whether it is drug-related.