Cabergoline is a long-acting dopamine D2 receptor agonist that selectively activates dopamine D2 receptors in the central nervous system and inhibits the secretion of prolactin (PRL) from the anterior pituitary gland.

1、 Drug name and main ingredients

1. Common name: Cabergoline

2. Product Name: Dostinex ® (Pfizer, USA)

3. Dosage form: Tablets

4. Main ingredients: Each tablet contains 0.25mg, 0.5mg, or 1mg of cabergoline, and excipients include D-mannitol, magnesium stearate, etc.

2、 Indications

Hyperprolactinemia: Treatment for high prolactin levels caused by menstrual disorders, infertility, excessive lactation, and pituitary tumors.

3、 Specifications and characteristics

1. Specification: 0.5mg

2. Appearance: Thin film coated sheet, with white crystalline solid content.

4、 Usage and dosage

1. Hyperprolactinemia: Initial 0.25mg twice a week, with increments of 0.25mg every 4 weeks based on prolactin levels, up to a maximum of 1mg per dose.

2. Medication time: It can be taken together with food to reduce nausea.

5、 Dose adjustment

1. Renal insufficiency: CrCl<50mL/min is prohibited.

2. Liver dysfunction: Child Pugh B/C grade is contraindicated.

6、 Medication precautions

1. Allergy screening: HLA-B * 5701 gene needs to be tested before medication.

2. Omission treatment: Take the medication immediately, and skip if it is close to the next medication time (within 4 hours).

3. Vomiting treatment: No need for supplementation, take the medication according to the original plan for the next time.

4. Fibrosis risk: Prior to treatment, cardiac ultrasound examination and regular monitoring of valve lesions are required.

7、 Medication for special populations

1. Pregnant women: prohibited (animal experiments show embryotoxicity).

2. Breastfeeding period: Continue breastfeeding at least one month after discontinuing medication.

3. Children: Prohibited for children under 15 years old.

8、 Adverse reactions

1. Common: Nausea (relieved when taken with food), headache, low blood pressure.

2. Serious: heart valve disease, pulmonary fibrosis, psychiatric symptoms (hallucinations, depression).

9、 Contraindications

1. Individuals allergic to ergot alkaloids;

2. Severe heart disease, uncontrolled hypertension;

3. Pregnancy or lactation period.

10、 Drug interactions

1. Antihypertensive drugs: To enhance the effect of lowering blood pressure, it is necessary to monitor blood pressure.

2. Dopamine antagonists (such as metoclopramide): reduce efficacy.

11、 Storage method

1. Store in a sealed environment at 20-25 ℃ to avoid moisture.

2. Valid for 24 months.

12、 Manufacturer

Original manufacturer: Pfizer from the United States.

Note: During treatment, regular monitoring of prolactin levels, cardiac function, and mental state is necessary to avoid taking aluminum/magnesium antacids together.

Cabergolineinformation