The medication time of Trabectedin should strictly follow the doctor's advice, usually administered through intravenous infusion, and the specific medication plan should be determined according to the treatment cycle and individual patient situation.

1. Standard dosing schedule

(1) Adult patients: Every 21 days is a treatment cycle, with medication administered once on the first day

(2) Infusion duration: Continuous infusion through a central venous catheter for 24 hours is required

(3) Cycle repetition: It needs to be carried out under professional medical supervision until the disease progresses or intolerable toxicity occurs

2. Medication duration for special populations

(1) Liver dysfunction: Patients with moderate to severe liver damage need to extend the dosing interval to 4-5 weeks

(2) Renal insufficiency: No need to adjust medication timing, but monitoring needs to be strengthened

(3) Elderly patients: Administration time is the same as the standard protocol, but adverse reactions need to be closely observed

3 Medication precautions

(1) Pre treatment requirements: Dexamethasone and other glucocorticoids should be used before administration to prevent infusion reactions

(2) Time adjustment: In the event of ≥ grade 3 adverse reactions, administration should be delayed until recovery is achieved

(3) Combination therapy: When used in combination with CYP3A inhibitors, the dosing interval needs to be adjusted