Trabectedin is a novel alkylating anti-tumor drug developed by Janssen, a subsidiary of Johnson&Johnson in the United States.

1、 Drug name and main ingredients

1. Common name: Trabectedin

2. Product Name: YONDELIS ®

3. Dosage form: Freeze dried powder injection for injection

4. Main ingredients: Each bottle contains 1mg of Qubetidine

2、 Indications

Liposarcoma or leiomyosarcoma: Used to treat adult patients with unresectable or metastatic liposarcoma or leiomyosarcoma who have previously received chemotherapy regimens containing anthracyclines.

3、 Specifications and characteristics

1. Specification: 1mg/bottle (single dose penicillin bottle freeze-dried powder).

2. Appearance: White to off white freeze-dried powder, dissolved to a colorless to light brownish yellow clear or microemulsion light solution.

4、 Usage and dosage

1. Recommended dose: 1.5mg/m ² body surface area, once every 3 weeks, continuously intravenously administered through a central venous catheter for 24 hours.

2. Preparation: Inject 20mg dexamethasone intravenously 30 minutes before each infusion.

3. Dissolve in 20mL sterile injection water per bottle, gently shake until completely dissolved, and then dilute in 500mL 0.9% sodium chloride or 5% glucose injection solution.

4. Infusion requirements: Use a 0.2 micron polyethersulfone (PES) online filter and complete the infusion within 30 hours.

5、 Dose adjustment

1. First reduction: 1.2mg/m ²; Secondary reduction: 1.0mg/m ².

2. Adjustment criteria: Adjust according to the grading of adverse reactions such as neutropenia, hepatotoxicity, elevated creatine kinase, or left ventricular dysfunction.

6、 Medication precautions

1. Infection risk: Screening for latent tuberculosis before treatment and monitoring neutrophil count;

2. Hepatotoxicity: Check liver function before each administration, pause when ALT/AST>2.5 times ULN;

3. Cardiac monitoring: Left ventricular function is evaluated every 2-3 months during treatment using echocardiography;

4. Infusion safety: Medication should only be administered through a central venous catheter to avoid tissue necrosis caused by extravasation.

7、 Medication for special populations

1. Pregnant women: prohibited (may cause fetal damage);

2. Breastfeeding period: Stop breastfeeding during treatment and within one week after discontinuation of medication;

3. Children: Safety has not been established;

4. Liver and kidney dysfunction: There is no recommended dose for patients with serum bilirubin>ULN or ALT/AST>2.5 times ULN.

8、 Adverse reactions

1. Common (≥ 20%): nausea (75%), fatigue (69%), vomiting (46%), constipation (37%), decreased appetite (37%);

2. Serious reactions: neutropenic sepsis (5%), rhabdomyolysis (0.8%), hepatotoxicity (35%), cardiomyopathy (6%).

9、 Contraindications

It is contraindicated for individuals with severe allergies to quetiapine or excipients.

10、 Drug interactions

1. Strong CYP3A inhibitors (such as ketoconazole): Avoid combination therapy and increase exposure to tramadol by 66%;

2. Strong CYP3A inducers (such as rifampicin): Avoid combination therapy and reduce exposure to tramadol by 31%.

11、 Storage method

Unopened penicillin bottles should be refrigerated at 2-8 ° C and stored away from light. After reconstitution, they should be used at room temperature for 1 hour or refrigerated for 4 hours.

12、 Manufacturer

Manufacturer: Janssen Products, LP (USA).

Note: If there is persistent infection, severe muscle pain, or abnormal liver function, seek medical attention immediately. Regular monitoring of blood routine, liver function, and heart function is required during the treatment period.

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