The side effects of dalafenib mesylate capsules mainly include skin reactions, fever, joint pain, etc. Most of them can be relieved through preventive measures or symptomatic treatment. Serious adverse reactions require timely medical intervention.

1. Common self relieving side effects

(1) Skin reaction: 86% of patients develop rash, 26% are grade 3, it is recommended to use non-alcoholic moisturizer and strengthen sun protection.

(2) Fever: The incidence rate is about 50%, which can be controlled by physical cooling or short-term use of antipyretics.

(3) Fatigue: Maintaining sufficient rest and completing daily activities in stages can improve symptoms.

2. Serious side effects requiring medical intervention

(1) Squamous cell carcinoma of the skin: undergo regular skin examinations and seek medical attention immediately upon discovering new skin lesions.

(2) Eye toxicity: 16% of patients develop keratitis and other conditions, requiring ophthalmic evaluation and medication suspension.

(3) Venous thromboembolism: incidence rate of 36%, requiring prophylactic anticoagulant therapy in the first 4 months.

3. Targeted mitigation measures

(1) Skin management: Wear protective clothing and use SPF30+sunscreen during treatment to avoid direct sunlight.

(2) Fever treatment: Suspend medication when body temperature exceeds 38.5 ℃, replenish fluids, and monitor vital signs.

(3) Joint pain: Non steroidal anti-inflammatory drugs can alleviate symptoms, and dosage adjustment is necessary in severe cases.

4. Special precautions

(1) Avoid using strong CYP3A4 inducers in combination, as it may affect drug metabolism.

(2) Women of childbearing age should take effective contraceptive measures until 4 weeks after discontinuing the medication.

(3) Patients with abnormal liver function need to adjust the dosage, and Child Pugh Class C is contraindicated.