The side effects of bimetinib require focused monitoring of cardiac, hepatic, and ocular toxicity, while also paying attention to standardized storage conditions. The following are specific management measures and storage requirements.

1. Side effect management measures

(1) Prevention and control of cardiac toxicity

Regularly monitor left ventricular ejection function and interrupt treatment immediately if symptoms such as palpitations and difficulty breathing occur. Echocardiography examination is recommended to be performed every 3 months. If LVEF decreases by more than 10%, medication should be reduced or discontinued.

(2) Hepatotoxicity monitoring

Check ALT/AST before treatment and monthly, and increase frequency when abnormal. If ALT/AST>3 times the normal value, medication should be temporarily suspended, and if accompanied by an increase in bilirubin, medication should be permanently discontinued.

(3) Retinopathy treatment

Immediate ophthalmic evaluation is required for blurred vision. If the treatment of serous retinopathy is temporarily suspended for 4 weeks and does not improve, the medication should be permanently discontinued. If retinal vein occlusion occurs, the medication should be terminated immediately.

(4) Skin cancer screening

During the treatment period, the skin should be checked every 2-3 months. For new warts, mole changes, or ulcers that do not heal, biopsy is required. Sunscreen requires the use of sunscreen with SPF ≥ 30.

(5) Prevention of bleeding risk

Avoid using anticoagulant drugs and seek medical attention immediately in case of abnormal bleeding. Intracranial hemorrhage requires permanent discontinuation of medication, while other bleeding events require dose adjustment based on severity.

2 Drug Storage Standards

(1) Temperature requirements

The storage temperature is between 20 ° C and 25 ° C, with short-term fluctuations allowed between 15 ° C and 30 ° C. Avoid freezing or high temperature environments.

(2) Packaging protection

Keep the original packaging away from light and moisture, and take it immediately after removal. The pill cannot be crushed or divided, and must be swallowed whole.

(3) Validity period management

Pay attention to the expiration date indicated on the packaging label, expired drugs need to be handled by professional institutions. Unused drugs should retain their original packaging and desiccants.