The side effects of Ixazomib include blood system abnormalities, gastrointestinal reactions, peripheral neuropathy, etc., which need to be alleviated through regular monitoring, symptomatic treatment, and lifestyle adjustments. Below is an explanation of common side effects classification and corresponding measures.

1. Hematological system side effects

(1) Thrombocytopenia: manifested as abnormal bleeding or bruising, requiring regular monitoring of platelet count, avoiding the use of sharp instruments, and administering platelets if necessary.

(2) Neutropenia: increases the risk of infection. If fever or infection symptoms occur, seek medical attention immediately and use granulocyte colony-stimulating factor if necessary.

2. Gastrointestinal reactions

(1) Diarrhea: Supplement water to prevent dehydration, use antidiarrheal drugs in severe cases, and avoid high fiber foods.

(2) Nausea and vomiting: Eat in small portions and the doctor may prescribe antiemetic drugs such as 5-HT3 receptor antagonists.

3. Neurological side effects

(1) Peripheral neuropathy: manifested as numbness or tingling in hands and feet, can be supplemented with B vitamins, and avoid contact with cold and hot stimuli.

(2) Dizziness: When getting up, move slowly to prevent falls. In severe cases, evaluate whether to adjust the dosage.

4. Other side effects that need attention

(1) Skin rash: Mild cases can be treated with antihistamines, while severe cases with fever require discontinuation of medication and medical attention.

(2) Abnormal liver function: Regularly test transaminases, avoid drinking alcohol, and seek liver protection treatment if necessary.