Vibegron, as a selective β 3-adrenergic receptor agonist, is mainly used to treat overactive bladder. Its mechanism of action and drug interactions require special attention to the monitoring of blood drug concentrations of drugs such as digoxin.

1. Effect of action

(1) Target effect: Specifically activate β 3-adrenergic receptors to improve urine storage function by relaxing the detrusor muscle of the bladder.

(2) Clinical effect: It can significantly reduce the frequency of urgent urinary incontinence and urination, and the 24-hour urination diary shows a symptom improvement rate of over 60%.

2. Drug interactions

(1) Digoxin: Vebeclone significantly increases the Cmax and AUC of digoxin, and serum digoxin concentration should be continuously monitored before, during, and after discontinuation of treatment.

(2) Bladder function impact: combined with anticholinergic drugs may increase the risk of urinary retention, and patients with dysuria need to seek medical advice immediately.

3. Precautions for use

(1) Monitoring requirements: It is recommended to conduct regular urodynamic tests during medication to evaluate bladder emptying function.

(2) Special population: Patients with severe liver and kidney dysfunction need to adjust their dosage, and it is recommended to reduce the initial dosage by half for elderly patients.