Allydone Patches, as a treatment for Alzheimer's disease, require strict evaluation of contraindications, dietary restrictions, and special limitations to ensure medication safety and effectiveness.

1. Taboo population

(1) Allergic individuals

Do not use for individuals allergic to donepezil or its excipients, as contact allergic reactions such as skin redness and itching may occur.

(2) Severe liver disease patients

It is contraindicated for patients with Child Pugh C grade liver dysfunction, as significant slowing of drug metabolism may lead to toxic accumulation.

(3) Specific heart disease patients

Patients with sick sinus syndrome or severe atrioventricular block should not use it, as it may worsen cardiac conduction abnormalities such as bradycardia.

2. Forbidden foods

(1) Grapefruit products

It is forbidden to consume grapefruit or fruit juice, as the furan coumarin it contains can inhibit CYP3A4 enzyme and increase blood drug concentration by more than 50%.

(2) High-fat diet

Avoid high-fat foods during application, as it may delay drug absorption and affect the maintenance of steady-state blood drug concentration.

3. Special Restrictions

(1) Skin condition restrictions

Patients with inflammatory skin diseases such as dermatitis and eczema need to evaluate the application site, as skin barrier disruption may increase absorption.

(2) Effect of body temperature

Monitoring is necessary when experiencing fever or prolonged exposure to high temperatures, as increased skin blood flow may lead to excessive drug release.

(3) Image inspection restrictions

Before MRI examination, the patch should be removed to avoid local heating effects caused by the metal backing, which could lead to skin burns.

4. Special population restrictions

(1) Prohibited for children

The safety of individuals under 18 years old has not been established, and overactivation of the cholinergic system may affect neurological development.

(2) Pregnancy risk

Animal studies have shown embryotoxicity, and pregnant women should not use it unless the potential benefits outweigh the risks.

(3) Breastfeeding period restrictions

Medications can be secreted into breast milk. During lactation, medication or breastfeeding should be stopped to avoid cholinergic side effects in infants.