Donepezil transdermal patch is a transdermal absorption preparation used for the treatment of Alzheimer's dementia. It reversibly inhibits acetylcholinesterase, increases acetylcholine levels in the brain, and improves cognitive function.

1、 Drug name

Common name: donepezil transdermal patch

Product Name: AllydonePatches

2、 Indications

Used for symptomatic treatment of Alzheimer's disease (acetylcholinesterase inhibitor type cognitive impairment).

3、 Specifications and characteristics

1. Specifications:

5mg/10cm ² (including 5mg of donepezil).

10mg/20cm ² (including 10mg of donepezil).

2. Characteristics:

The appearance is a patch with a sticky protective pad, and the substrate is white to off white.

The back of the patch is printed with a specification label (such as "5" or "10").

4、 Main components

Active ingredient: donepezil.

Accessories include: acrylic pressure-sensitive adhesive, siliconized polyester film, polyethylene backing, etc.

4、 Usage and dosage

1. Initial dose: 5mg patch once daily.

2. Maintenance dose: After 4 weeks of treatment, the dosage can be increased to once daily, 10mg patch, depending on tolerance.

3. Apply to clean and dry areas with intact skin, such as the upper back, lower back, upper arms, or chest.

4. Application time: Replace every 24 hours, and it is recommended to use it regularly.

5、 Dose adjustment

1. For patients with liver dysfunction: the initial dose should be reduced to 2.5mg.

2. Leakage treatment: If you forget to apply it, you should reapply it as soon as possible; If it is close to the next medication time, skip this dose.

6、 Medication precautions

1. Before and after meals: No need to associate with meal times.

2. Vomiting management: If severe vomiting occurs, medication should be suspended and a doctor should be consulted.

7、 Medication for special populations

1. Pregnant women: There is currently insufficient research data, so it is necessary to weigh the pros and cons.

2. Breastfeeding women: It is recommended to stop breastfeeding during medication.

3. Children: Safety and efficacy have not been established.

4. Elderly: No special dosage adjustment is required, but adverse reactions need to be monitored.

8、 Adverse reactions

Common symptoms: nausea, vomiting, diarrhea, dizziness, insomnia.

Rare: bradycardia, epileptic seizures, extrapyramidal symptoms.

9、 Contraindications

1. Individuals who are allergic to any ingredient in donepezil or patches.

2. Patients with severe liver dysfunction.

3. There are contraindications when combined with certain antiarrhythmic drugs.

10、 Drug interactions

1. Co administration with cholinergic drugs (such as choline) may enhance the effect.

2. Co administration with anticholinergic drugs (such as atropine) may weaken the therapeutic effect.

11、 Storage method

1. Storage temperature: not exceeding 30 ° C.

2. Keep away from moisture and light, and maintain the original packaging until use.

3. Keep out of reach of children.

12、 Manufacturer

Japan Xinghe Corporation.

13、 Other important information

1. The application area should be changed alternately to avoid continuous use of the same area.

2. Clean the skin before use to ensure no damage, inflammation, or hair.

3. After application, press to ensure a snug fit and avoid contact with water sources.

Allydone Patchesinformation