As a commonly used medication for acne treatment and leukemia management, tretinoin has clear contraindications, dietary restrictions, and special conditions that need to be strictly followed to avoid serious adverse reactions.

1. Taboo population

(1) Pregnant women

Prohibited during pregnancy, animal experiments have shown teratogenic risks, and human data confirms that early exposure during pregnancy can lead to craniofacial deformities and central nervous system defects.

(2) Lactating women

Medication can be secreted into breast milk, which may cause symptoms of excessive vitamin A in infants. Medication should be temporarily suspended or breastfeeding should be stopped during lactation.

(3) Children

Caution should be exercised when using topically for children under 12 years old. Oral preparations are prohibited for indications other than acute promyelocytic leukemia.

(4) Liver dysfunction

Patients with severe liver function impairment should avoid oral preparations as metabolic disorders may lead to drug accumulation and poisoning.

2. Forbidden foods

(1) High-fat diet

Oral preparations taken together with high-fat meals can increase absorption rate by 300%, which may induce acute pancreatitis. It is recommended to take on an empty stomach.

(2) Alcohol

Intensify skin dryness and liver metabolic burden, and quit drinking during treatment.

(3) Vitamin A supplements

Do not use in combination as it may cause symptoms of vitamin A poisoning such as headache and papilledema.

3. Restrictive conditions

(1) Photosensitive sensitivity

During the treatment period, strict sun protection is required to avoid exposure sources such as sunbathing and UV therapy. Physical sun protection measures should be used when going out.

(2) Skin condition

When the skin barrier is damaged due to eczema, sunburn, etc., external use should be temporarily suspended, otherwise it may worsen the irritation reaction.

(3) Drug combination therapy

Prohibition of combination with tetracycline and fluoroquinolone antibiotics, which may enhance phototoxicity; Avoid using skincare products containing benzalkonium chloride in combination.

(4) Special operations

During the treatment period, invasive procedures such as laser beauty and chemical exfoliation are prohibited, and medication must be stopped for one month before implementation.