Anagrelide, as a specific drug for the treatment of thrombocytosis, should be adjusted in dosage and administration according to patient type and individual differences, and caution should be exercised when using it for special populations. This article will systematically explain the standard dosage regimen, dosage adjustment principles, and medication precautions for special populations of this drug.

1. Usage and dosage

(1) Adult thrombocytosis: The initial dose is 0.5 milligrams per dose, 4 times a day, or 1 milligrams per dose, 2 times a day. The maintenance dose needs to be adjusted to the lowest effective dose that can control platelet count below 600000 per microliter, with a weekly increase not exceeding 0.5 milligrams per day.

(2) Children's patients: The recommended initial dose is 0.5 milligrams per day, which can be increased to 0.5 milligrams per dose four times a day. The principle for adjusting the maintenance dose is the same as that for adults, with a maximum dose not exceeding 10 milligrams per day.

(3) Dose adjustment: Most patients can take effect with 1.5-3 milligrams per day, and platelet count usually begins to decrease within 7-14 days. Patients with liver dysfunction should reduce their dosage, and severe liver dysfunction should be avoided.

2. Medication for special populations

(1) Breastfeeding period: Medications may enter breast milk. It is recommended to stop breastfeeding or discontinue medication to avoid potential risks to the infant.

(2) Children's use: Medication data from patients aged 7-14 indicate no significant difference in dosage and adverse reactions compared to adults, but close monitoring is still necessary.

(3) Elderly patients: Patients aged 65 and above have similar therapeutic effects as young adults, but caution should be exercised when using due to decreased liver and kidney function.

(4) Liver dysfunction: Mild to moderate patients need to reduce dosage and monitor cardiovascular toxicity, while severe patients are contraindicated.

(5) Renal insufficiency: Close monitoring of cardiovascular effects and other toxic manifestations is necessary, and dosage adjustments may be necessary.

3. Medication precautions

(1) Omission treatment: Take the medication as soon as possible, skip if it is close to the next medication time, and prohibit double dose supplementation.

(2) Overdose treatment: The standard for overdose is not yet clear, and if suspected overdose occurs, immediate medical attention should be sought for symptomatic treatment.

(3) Monitoring requirements: During treatment, platelet count, liver function, and cardiovascular function should be regularly checked.