Anagrelide is effective in treating thrombocytosis, but attention should be paid to the risk of rebound thrombocytosis when discontinuing the medication. The following text will provide detailed explanations from two aspects: treatment effectiveness and medication discontinuation precautions.

1. Therapeutic effect

(1) Effective time: The effect of platelet count decrease usually begins to appear 7-14 days after treatment, which can effectively control platelets within a safe range.

(2) Therapeutic effect maintenance: Long term use can stably control platelet count, reduce the risk of thrombosis and bleeding events.

(3) Special populations: The efficacy in children and elderly patients is comparable to that in adults, but the dosage needs to be adjusted according to individual circumstances.

2. Precautions for discontinuation of medication

(1) Risk of rebound: Sudden discontinuation of medication may lead to a rapid increase in platelet count within 4 days, and sudden interruption of treatment should be avoided.

(2) Reduce dosage and stop taking medication: If medication needs to be stopped, it should be gradually reduced under the guidance of a doctor, rather than immediately stopping completely.

(3) Monitoring requirements: Regular monitoring of platelet count is still necessary after discontinuation of medication to prevent rebound thrombocytosis.

(4) Special circumstances: When serious side effects occur and the medication needs to be stopped immediately, platelet changes should be closely monitored and corresponding measures should be taken.

Overall, the treatment effect of Anagrel is good, but caution should be exercised during the discontinuation process. It is recommended to follow the guidance of a doctor and carry out relevant monitoring work.