Common side effects of Brilinta include increased risk of bleeding, difficulty breathing, gastrointestinal discomfort, etc., which can be alleviated by adjusting dosage, symptomatic treatment, and regular monitoring. The following will explain the classification of side effects and corresponding measures.

1. Common side effects and mitigation methods

(1) Risk of bleeding

Ticagrelor may cause bleeding (such as nosebleeds, gum bleeding), and in severe cases can lead to intracranial hemorrhage. During medication, avoid trauma and use a soft bristled toothbrush; If surgery is required, the doctor should be informed in advance to stop medication for 5-7 days.

(2) Difficulty breathing

About 15% of patients experience difficulty breathing after medication, which is usually mild and reversible. If the symptoms persist or worsen, it is necessary to evaluate whether dressing change is necessary, and if necessary, oxygen therapy should be administered for relief.

2. Management of other adverse reactions

(3) Gastrointestinal reactions

Nausea, diarrhea, etc. can be relieved by taking medication in divided doses and after meals. Severe vomiting or diarrhea requires fluid replacement to prevent dehydration, and antiemetic drugs may be used in combination if necessary.

(4) Bradycardia

Monitor heart rate and perform electrocardiogram examination when dizziness or fainting occurs. Caution should be exercised when using beta blockers in combination, and the dosage should be adjusted if necessary.

3 Special precautions

(5) Drug interactions

Avoid using potent CYP3A4 inhibitors (such as clarithromycin) in combination, as it may increase blood drug concentrations. When used in combination with aspirin, the recommended dosage for the latter is ≤ 100mg/day.

(6) Monitoring requirements

Regularly check blood routine (focusing on platelets), liver function, and kidney function. If there are bruises, hematuria or jaundice, seek medical attention immediately.

(7) Drug interaction contraindications: Avoid co administration of potent CYP3A4 inducers (such as rifampicin) or inhibitors (such as ketoconazole), as they may affect drug efficacy or increase toxicity. The dosage of aspirin should be controlled between 75-100mg/day.