Clopidogrel Bisulfate is an oral thienopyridine antiplatelet drug that inhibits platelet aggregation by irreversibly inhibiting the P2Y12 ADP receptor on the platelet surface.

I. Patients with Active Bleeding

Absolutely contraindicated: Clopidogrel is contraindicated in patients with active pathological bleeding (such as bleeding from peptic ulcer, intracranial hemorrhage, active menorrhagia, etc.), because it inhibits platelet aggregation, which can aggravate bleeding and delay hemostasis.

Use with caution in patients with bleeding tendency: For patients with a history of bleeding disorders, coagulation dysfunction, or recent major surgery, the decision to use the drug must be made by a physician after full risk assessment.

Monitoring during medication: If black stools, hematemesis, hematuria, large subcutaneous ecchymosis, persistent epistaxis, etc. occur during medication, seek medical attention immediately; if necessary, discontinue the drug and take hemostatic measures.

II. Patients with Severe Hepatic Impairment

Use with caution or contraindicated: Patients with severe hepatic impairment (such as Child-Pugh class C) should use it with caution or avoid it. Clopidogrel requires hepatic metabolism to be converted into its active component, and severe liver impairment may affect efficacy; meanwhile, such patients often have impaired synthesis of coagulation factors and a higher risk of bleeding.

Assessment before medication: Patients with mild to moderate hepatic impairment may use it under physician monitoring, and liver function and coagulation indicators should be checked before medication.

Regular follow-up: During medication, regularly monitor liver function, coagulation function, and signs of bleeding; seek medical attention promptly if abnormalities such as jaundice, worsened fatigue, or gum bleeding occur.

III. Other Related Contraindications and Precautions

Contraindicated in allergic individuals: Contraindicated in patients allergic to clopidogrel or the excipients of this product.

Caution with concomitant medications: Concomitant use with anticoagulants, nonsteroidal anti-inflammatory drugs, or other antiplatelet drugs increases the risk of bleeding; follow the physician's instructions and strengthen monitoring.

Special populations: Use during pregnancy, lactation, and in children requires a physician to weigh the benefits and risks; do not use on your own.

IV. Important Reminders

Before medication, please proactively inform the physician of your bleeding history, liver disease history, and all medications you are currently taking.

This notice is for reference only. For specific contraindications and medication plans, please refer to the physician's prescription and the drug package insert.