Chlorphenesin Carbamate tablets from Japan are central muscle relaxants that have the effect of relieving skeletal muscle spasms, and their efficacy and drug interactions require special attention.

1. Effect of action

(1) Mechanism of action: By inhibiting spinal cord and polysynaptic reflexes, reducing muscle spindle sensitivity, and blocking abnormal nerve impulse transmission;

(2) Effective time: The peak blood drug level is reached 1-2 hours after oral administration, and the effect lasts for 4-6 hours;

(3) Indications: Mainly used to relieve muscle spasmodic diseases such as lower back pain, fibromyalgia syndrome, etc.

2. Treatment effect

(1) Clinical efficacy: can reduce muscle spasm frequency by 50% -70% and improve joint range of motion;

(2) Therapeutic effect differences: Individual differences are significant, and some patients need 2-3 weeks to achieve optimal results;

(3) Efficacy evaluation: The main evaluation indicators are muscle tone reduction and pain relief.

3. Drug interactions

(1) Central nervous system inhibitors: When used in combination with alcohol and benzodiazepines, they can enhance sedative effects and require dosage adjustment;

(2) Liver enzyme inducers: Barbital drugs may accelerate their metabolism and reduce blood drug concentrations;

(3) Muscle relaxants: Combination with other neuromuscular blockers may increase the risk of respiratory depression;

(4) Anticholinergic drugs: may enhance adverse reactions such as dry mouth and constipation;

(5) Diuretics: Electrolyte imbalance may enhance their neuromuscular blocking effect.

4. Precautions for discontinuation of medication

(1) Symptom rebound: Sudden discontinuation of medication may worsen muscle spasms, and the dosage should be reduced again after returning to the lowest effective dose;

(2) Central reaction: Long term medication users may experience withdrawal symptoms such as anxiety and insomnia, and short-term use of benzodiazepines may be necessary;

(3) Functional assessment: Regularly evaluate daily activity ability and adjust rehabilitation training intensity during drug discontinuation.