Xphozah is a phosphorus lowering drug used for the treatment of hyperphosphatemia in dialysis patients. It is necessary to strictly follow the medication guidelines and pay attention to potential side effect risks, especially for special medication adjustments for dialysis patients.

Medication Guide for Dialysis Patients

1. Basic dose plan

The starting dose for dialysis patients is usually 800mg per day, taken twice with meals. The dose should be adjusted every 2-4 weeks based on blood phosphorus levels, and the maximum daily dose should not exceed 3000mg.

2. Adjustment of dialysis days

Hemodialysis patients should take medication after dialysis, while peritoneal dialysis patients should avoid the dialysis fluid exchange period and maintain a relatively fixed dosing time.

3. Blood phosphorus monitoring

During the initial stage of treatment, serum phosphorus concentration is monitored weekly, and after stabilization, monthly testing is required. Additional monitoring is needed before and after dialysis to prevent excessive fluctuations in phosphorus levels.

Precautions for special populations

4. Renal function adjustment

Patients with end-stage renal disease do not need to adjust their dosage, but close monitoring of blood phosphorus and blood calcium levels is necessary to prevent hypophosphatemia or electrolyte imbalance.

5. Combination therapy

Take aluminum/magnesium antacids at an interval of 2 hours and iron antacids at an interval of 1 hour to avoid affecting drug absorption.

Common Side Effect Management

6. Gastrointestinal reactions

Diarrhea (incidence rate of 15% -20%) is mostly mild and can be relieved by taking it with meals in divided doses. If it persists, it needs to be reduced.

7. Abnormal electrolyte

May cause hypocalcemia (5% -10%), manifested as muscle spasms, requiring regular monitoring and calcium supplementation.

Serious adverse reaction management

8. Deterioration of hyperphosphatemia

If blood phosphorus levels remain above 5.5mg/dL for more than 4 weeks, medication adherence should be evaluated and consideration should be given to combining other phosphate lowering treatments.

9. Allergic reactions

If rash or facial edema occurs, the medication should be stopped immediately. Severe allergic reactions require emergency treatment with adrenaline.

Key points of medication education

10. Dietary coordination

It is necessary to synchronously control the intake of high phosphorus diets to avoid the impact of high phosphorus foods such as dairy products and nuts on the therapeutic effect.

11. Handling of missed services

If the missed dose does not exceed 6 hours, it can be supplemented. If it is close to the next administration time, it should be skipped. Double dose compensation is prohibited.