Relugolix exerts its antitumor effect by suppressing testosterone. Hot flashes, fatigue, and weight gain are common adverse reactions, most of which can be relieved through symptomatic adjustment and lifestyle management.

I. Managing Hot Flashes

1.Understand the Characteristics

Hot flashes present as sudden warmth and sweating in the face, neck, and upper body, are short in duration, and often recur; they are a common reaction after hormone suppression.

2.Environmental Adjustment

Keep the room cool, wear breathable clothing that can be layered, and carry a fan or cool towel.

3.Avoid Triggers

Reduce spicy foods, alcohol, caffeine, and hot drinks, and avoid sudden entry into hot environments.

4.Regular Exercise

Moderate aerobic exercise helps regulate body temperature and mood, but avoid strenuous exercise during hot periods.

5.Seek Medical Attention Promptly

When hot flashes severely affect sleep or daily life, inform the doctor to assess whether drug intervention is needed; do not use hormone products on your own.

II. Managing Fatigue

1.Ensure Rest

Maintain a regular schedule, take appropriate naps during the day, and avoid staying up late and overexertion.

2.Moderate Activity

Light to moderate exercise(such as walking and stretching) can improve energy; avoid prolonged bed rest and inactivity.

3.Balanced Diet

Ensure protein and calorie intake, eat small frequent meals, and avoid malnutrition due to decreased appetite.

4.Rule Out Other Causes

When fatigue worsens, check hemoglobin, thyroid function, and liver function to rule out correctable factors such as anemia and endocrine abnormalities.

5.Allocate Energy Reasonably

Schedule important activities during periods of better energy, and ask family for help with daily tasks when necessary.

III. Managing Weight Gain

1.Monitor Weight

Weigh yourself at a fixed time each week and record it to detect upward trends early.

2.Control Diet

Reduce high-sugar and high-fat foods, increase vegetables and high-quality protein, control total calories, and avoid emotional eating.

3.Persist in Exercise

Perform appropriate aerobic and resistance exercise weekly to help maintain muscle mass and basal metabolism.

4.Pay Attention to Metabolic Indicators

Weight gain is often accompanied by changes in blood glucose and lipids; have regular follow-up tests and seek assistance from nutrition or endocrinology departments when necessary.

5.Do Not Reduce Medication on Your Own

Do not stop or reduce the medication on your own because of weight changes; regimen adjustments must be decided by the doctor.

6.Comprehensive Follow-up

The above symptoms often occur together; report regularly to the doctor and, combined with PSA and testosterone monitoring, comprehensively assess treatment benefit and tolerability.