Voxzogo(vosoritide)is used to treat achondroplasia,but it is not suitable for all patients.Patients with severe renal impairment and those allergic to any component of this product require special attention.The following is relevant information.

I.Patients with Severe Renal Impairment

1.Why It Is Contraindicated

Vosoritide is mainly metabolized and cleared by the kidneys.

Severe renal impairment can slow drug clearance and increase the risk of accumulation in the body.

It may worsen adverse reactions such as hypotension and vomiting.

2.Assessment Before Treatment

Renal function should be tested before starting treatment to determine the glomerular filtration rate.

If severe renal impairment is present,this product should not be used.

Patients with mild to moderate renal impairment require careful use after evaluation by a doctor.

3.Monitoring During Treatment

Recheck renal function regularly and observe changes in indicators.

If renal function worsens,inform the doctor promptly to evaluate whether to discontinue the drug.

Pay attention to abnormal signs such as changes in urine output and edema.

II.Patients Allergic to Any Component of This Product

1.Scope of Contraindication

Contraindicated in patients with known allergy to vosoritide or any excipient.

Patients who have experienced severe allergic reactions should not use it again.

2.Manifestations of Allergy

Rash,urticaria,itching.

Swelling of the face,lips,tongue,or throat.

Difficulty breathing,wheezing,chest tightness.

Dizziness,palpitations,confusion.

3.Response Measures

Inform the doctor in detail of any allergy history before treatment.

If allergic symptoms occur,stop the drug immediately and seek medical attention.

Severe allergic reactions require emergency treatment and must not be observed on your own.

III.Other Precautions

1.Special Populations

Use in pregnant or breastfeeding women requires weighing benefits and risks.

Use in children should be under a doctor's guidance.

Elderly patients should be evaluated for renal function before use.

2.Drug Interactions

Inform the doctor of all medications being used.

Avoid concomitant use with drugs that may affect renal function or blood pressure.

3.Principles of Safe Medication Use

Strictly follow the doctor's instructions and do not adjust the dose on your own.

Follow up regularly to monitor efficacy and adverse reactions.

Seek medical attention promptly if discomfort occurs,and do not stop or change the medication on your own.