Vosoritide(Voxzogo)is used to treat achondroplasia and requires daily subcutaneous injection.Correctly mastering the dosage and precautions is key to ensuring efficacy and safety.

I.Dosage and Administration

1.Route of Administration

Once daily,subcutaneous injection.

Injection sites may include the thigh,abdomen,or upper arm.

Change the injection site each time,and avoid repeated injection at the same site.

2.Dosage Principles

The dose is calculated based on body weight and determined by the doctor.

Inject strictly according to the prescribed dose;do not increase or decrease it on your own.

If a dose is missed,inject it as soon as possible,and then resume the original schedule.

3.Preparation Before Injection

After removing from the refrigerator,allow it to reach room temperature.

Check whether the solution is clear and free of particles or discoloration.

Prepare alcohol wipes,a syringe,and a sharps container.

II.Precautions

1.Hypotension

Dizziness,fatigue,and blurred vision may occur.

Move slowly when changing position,and avoid standing up suddenly.

Ensure adequate fluid intake,and seek medical attention immediately if syncope occurs.

2.Injection Site Reactions

Pain,redness,swelling,itching,or induration are common.

Change the injection site each time,and do not rub the injection area.

Seek medical attention promptly if the local reaction is severe or pus develops.

3.Vomiting

Avoid greasy and spicy foods before and after injection.

Eat small frequent meals,and ensure fluid intake.

Seek medical attention promptly if vomiting persists or dehydration occurs.

4.Joint Pain

Rest appropriately,and avoid overusing the painful joint.

Local heat or cold compresses may relieve symptoms.

Inform the doctor if pain worsens or affects activity.

III.Drug Interactions and Storage

1.Drug Interactions

Inform the doctor of all medications being used.

Concomitant use with antihypertensives or diuretics may worsen hypotension.

Do not add or stop any medication on your own.

2.Storage Requirements

Refrigerate at 2°C to 8°C,and protect from light.

Do not freeze,and do not expose to heat sources or direct sunlight.

Immediately discard the needle into a sharps container after use.

IV.Comprehensive Recommendations

Strictly follow the doctor's instructions,and do not adjust the dose on your own.

Record injection time,site,and body reactions.

Follow up regularly to monitor efficacy and adverse reactions.

Seek medical attention promptly if severe discomfort occurs,and do not stop the medication on your own.