Proper use of Abemaciclib is the foundation for ensuring efficacy and controlling adverse reactions. The core principle is to take with meals to alleviate gastrointestinal discomfort and adjust the dosage flexibly based on adverse reactions. The following are specific operational points.

1. Take with meals and daily operations

1.1 Fixed meals included

It is recommended to take medication with breakfast or dinner every day. Food can buffer the stimulation of drugs on the gastrointestinal tract, reducing reactions such as diarrhea and nausea.

1.2 Whole pill swallowed

Please swallow the pill completely, without crushing, chewing or breaking it open, to avoid affecting the efficacy or increasing irritation.

1.3 Daily Schedule

Try to take medication at the same time every day to maintain a stable blood drug concentration. If there is a change in meal time, it can be adjusted slightly, but the interval should not be too long.

2. Principle of dose adjustment

2.1 Adjustment based on adverse reactions

When severe or persistent side effects such as diarrhea and decreased blood cells occur, medication can be temporarily suspended or the dosage reduced (such as from 150mg to 100mg or 50mg) under the guidance of a doctor.

2.2 Recovery and Quantity Increase

After the symptoms have eased to mild or disappeared, treatment can be resumed at the original dose or slightly lower dose. It is not recommended to increase the dose on your own.

2.3 Individualized Plan

Dose adjustment should be individualized and judged by doctors based on tolerance and examination results. It is not allowed to apply other people's plans.

3. Handling of missed services

3.1 Short term missed service

If you miss the medication time and it is more than 6 hours before the next medication, you can take it as soon as possible.

3.2 Approaching the next medication time

If it is less than 6 hours, skip the missed dose and take the next dose on time. Do not double the dosage.

3.3 Post vomiting treatment

If you vomit after taking the medication, there is no need to take it again. You can take the medication normally next time to avoid overdose.