The standardized use of Ruxolitinib directly affects the efficacy and safety. Mastering the correct way of taking medication, principles of dosage adjustment, and methods for handling missed doses are key to ensuring smooth treatment.

1、 How to take: on an empty stomach or with meals?

1. Can be taken with food or on an empty stomach

The absorption of Ruxolitinib is not significantly affected by food, and patients can choose to take it on an empty stomach or with meals according to their personal habits, without strict restrictions.

2. Maintain a fixed daily time

It is recommended to take medication at the same time every day to maintain a stable blood drug concentration and reduce the impact of concentration fluctuations on efficacy.

3. Swallow the whole pill, do not crush or chew it

Tablets should be taken whole with water and should not be crushed, broken or chewed to avoid altering the drug release characteristics.

2、 Principle of dose adjustment

1. The initial dose is based on baseline platelet count

Platelet count ≥ 200 × 10 ⁹/L: The recommended starting dose is 20mg twice daily.

Platelet count 100-200 × 10 ⁹/L: The recommended starting dose is 15mg twice daily.

Platelet count 50~<100 × 10 ⁹/L: The recommended starting dose is 5mg twice a day.

2. Dose adjustment during treatment

Recheck the blood routine every 2-4 weeks, and the doctor will decide whether to increase or decrease the dosage based on changes in platelet and neutrophil counts and therapeutic response. The typical adjustment range is 5mg twice a day.

3. Reduction is required for liver dysfunction

For patients with moderate (Child Pugh B) or severe (Child Pugh C) liver function impairment, the recommended dose should be reduced by about 50% compared to routine, and specific instructions should be followed according to medical advice.

3、 Handling methods for missed services

1. Leakage time<12 hours

If it is more than 12 hours before the next medication, the dose should be replenished as soon as possible.

2. Missed service time ≥ 12 hours

If it is close to the next medication time (less than 12 hours), skip the missed dose and take the next dose according to the original plan. Do not double the dose.

3. Do not double the dosage on your own

Under no circumstances should double the dosage be taken at once to avoid increasing the risk of serious adverse reactions such as bone marrow suppression.